IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer’s Disease

IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder that causes the most prevalent dementia in the elderly people. Obesity and insulin resistance, which may cause major health problems <i>per se</i>, are risk factors for AD, and cytokines such as interleukin-6 (IL-6) have a role in...

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Bibliographic Details
Main Authors: Anna Escrig, Amalia Molinero, Brenda Méndez, Mercedes Giralt, Gemma Comes, Paula Sanchis, Olaya Fernández-Gayol, Lydia Giménez-Llort, Christoph Becker-Pauly, Stefan Rose-John, Juan Hidalgo
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
Alzheimer’s disease
IL-6
IL-6 trans-signaling
body weight
high-fat diet
insulin
Online Access:https://www.mdpi.com/2073-4409/9/7/1605

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