Time course of current of injury is related to acute stability of active-fixation pacing leads in rabbits.
BACKGROUND: Magnitude of current of injury (COI) consequent to pacemaker lead fixation is recognized as a predictor of acute lead stability. It is unclear whether dynamic monitoring of COI after lead fixation provides additional information beyond a single assessment performed at the time of fixatio...
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doaj-f0188fe6e2f44161b96c09a21af4dd602020-11-25T01:19:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5772710.1371/journal.pone.0057727Time course of current of injury is related to acute stability of active-fixation pacing leads in rabbits.Shalaimaiti ShaliAlimujiang WushouEntao LiuLin JiaRuiming YaoYangang SuJunbo GeBACKGROUND: Magnitude of current of injury (COI) consequent to pacemaker lead fixation is recognized as a predictor of acute lead stability. It is unclear whether dynamic monitoring of COI after lead fixation provides additional information beyond a single assessment performed at the time of fixation. OBJECTIVES: This study was aimed to test the hypothesis that the time course of COI is related to acute lead stability. METHODS AND RESULTS: Active fixation leads with fixed screw were anchored to either Langendorff-perfused rabbit hearts endocardially or in vivo hearts epicardially in manners of contact the helix with no rotation, half rotation and full rotation, respectively. Intracardiac electrogram (EGM) was monitored dynamically from onset to resolution of COI, and magnitudes of intrinsic R wave and COI, including ST-segment elevation, ST/R and intracardiac EGM duration (IED), were measured. A digital force gauge was applied to assess lead stability. In vitro, COI in contacted leads was significantly smaller than those in half rotated (p<0.05) and fully rotated leads (p<0.05), and presented most precipitous recovery to baseline (1.5±1.1 min, p<0.05). Half-rotated and fully rotated leads manifested the same magnitude of COI right after placement. However, the time course of COI was significantly longer in fully rotated leads than that in half rotated leads (26.5±2.8 min vs. 5.6±2.0 min, p<0.05). Similar findings were observed in vivo. The time course of COI was significantly correlated with the force needed to detach the lead from myocardium (r = 0. 72, n = 48, p<0.001). CONCLUSIONS: Time course of COI is related to acute lead stability in rabbits. One might be misled by a single assessment of COI magnitude right after lead placement, whereas persistence of COI is likely to be a useful indicator of adequate lead stability.http://europepmc.org/articles/PMC3589396?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shalaimaiti Shali Alimujiang Wushou Entao Liu Lin Jia Ruiming Yao Yangang Su Junbo Ge |
spellingShingle |
Shalaimaiti Shali Alimujiang Wushou Entao Liu Lin Jia Ruiming Yao Yangang Su Junbo Ge Time course of current of injury is related to acute stability of active-fixation pacing leads in rabbits. PLoS ONE |
author_facet |
Shalaimaiti Shali Alimujiang Wushou Entao Liu Lin Jia Ruiming Yao Yangang Su Junbo Ge |
author_sort |
Shalaimaiti Shali |
title |
Time course of current of injury is related to acute stability of active-fixation pacing leads in rabbits. |
title_short |
Time course of current of injury is related to acute stability of active-fixation pacing leads in rabbits. |
title_full |
Time course of current of injury is related to acute stability of active-fixation pacing leads in rabbits. |
title_fullStr |
Time course of current of injury is related to acute stability of active-fixation pacing leads in rabbits. |
title_full_unstemmed |
Time course of current of injury is related to acute stability of active-fixation pacing leads in rabbits. |
title_sort |
time course of current of injury is related to acute stability of active-fixation pacing leads in rabbits. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
BACKGROUND: Magnitude of current of injury (COI) consequent to pacemaker lead fixation is recognized as a predictor of acute lead stability. It is unclear whether dynamic monitoring of COI after lead fixation provides additional information beyond a single assessment performed at the time of fixation. OBJECTIVES: This study was aimed to test the hypothesis that the time course of COI is related to acute lead stability. METHODS AND RESULTS: Active fixation leads with fixed screw were anchored to either Langendorff-perfused rabbit hearts endocardially or in vivo hearts epicardially in manners of contact the helix with no rotation, half rotation and full rotation, respectively. Intracardiac electrogram (EGM) was monitored dynamically from onset to resolution of COI, and magnitudes of intrinsic R wave and COI, including ST-segment elevation, ST/R and intracardiac EGM duration (IED), were measured. A digital force gauge was applied to assess lead stability. In vitro, COI in contacted leads was significantly smaller than those in half rotated (p<0.05) and fully rotated leads (p<0.05), and presented most precipitous recovery to baseline (1.5±1.1 min, p<0.05). Half-rotated and fully rotated leads manifested the same magnitude of COI right after placement. However, the time course of COI was significantly longer in fully rotated leads than that in half rotated leads (26.5±2.8 min vs. 5.6±2.0 min, p<0.05). Similar findings were observed in vivo. The time course of COI was significantly correlated with the force needed to detach the lead from myocardium (r = 0. 72, n = 48, p<0.001). CONCLUSIONS: Time course of COI is related to acute lead stability in rabbits. One might be misled by a single assessment of COI magnitude right after lead placement, whereas persistence of COI is likely to be a useful indicator of adequate lead stability. |
url |
http://europepmc.org/articles/PMC3589396?pdf=render |
work_keys_str_mv |
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