Correlation between patients’ age and cancer immunotherapy efficacy
Background: Although immunosenescence-induced difference on overall immune function and immune cell subsets between younger and older populations has been well characterized, the potential effect of patients’ age on the efficacy of immune checkpoint inhibitors (ICIs) remains little known. We perform...
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Online Access: | http://dx.doi.org/10.1080/2162402X.2019.1568810 |
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doaj-f030d99d39b64bba926275d009ad8c5f2020-11-25T03:28:12ZengTaylor & Francis GroupOncoImmunology2162-402X2019-04-018410.1080/2162402X.2019.15688101568810Correlation between patients’ age and cancer immunotherapy efficacyQiong Wu0Qiuhong Wang1Xin Tang2Ran Xu3Luzhong Zhang4Xinming Chen5Qun Xue6Ziheng Wang7Rongfeng Shi8Feiran Wang9Fei Ju10Bo Zhang11You Lang Zhou12Medical school, Nantong universityAffiliated Hospital of Nantong UniversityNantong UniversityMedical school, Nantong universityNantong UniversityAffiliated Hospital of Nantong UniversityAffiliated Hospital of Nantong UniversityNantong University Xinling collegeAffiliated Hospital of Nantong UniversityAffiliated Hospital of Nantong UniversityAffiliated Hospital of Nantong UniversityAffiliated Hospital of Nantong UniversityAffiliated Hospital of Nantong UniversityBackground: Although immunosenescence-induced difference on overall immune function and immune cell subsets between younger and older populations has been well characterized, the potential effect of patients’ age on the efficacy of immune checkpoint inhibitors (ICIs) remains little known. We performed a meta-analysis to investigate whether age differences play a role in cancer immunotherapy efficacy based on a large amount of clinical data. Methods: We conducted a systematic search of PubMed, Embase and MEDLINE for relevant randomized controlled trials. The primary outcome was overall survival (OS) and progression-free survival (PFS) was secondary outcome. The interaction test was used to assess the heterogeneity of HR between younger and older groups. Results: In total, 19 clinical randomized trials involving 11157 patients were included. The pooled HR for OS was 0.73 (95% CI 0.69–0.78) and 0.63 (95% CI 0.52–0.73) for PFS in younger patients receiving ICIs treatments, when compared with younger patients treated with controls. For older patients treated with ICIs, the pooled HR for OS compared with controls was 0.64 (95% CI 0.59–0.69) and 0.66 (95% CI 0.58–0.74) for PFS. The difference on OS efficacy between younger and older patients treated with ICIs was significant (Pheterogeneity = 0.025). Conclusions: Immune checkpoint inhibitors significantly improved OS and PFS in both younger and older patients compared with controls, but the magnitude of benefit was clinically age-dependent. Patients ≥65 y can benefit more from immunotherapy than younger patients. Future research should take age difference into consideration in trials and focus on tolerance and toxicity of ICIs in older patients.http://dx.doi.org/10.1080/2162402X.2019.1568810immune checkpoint inhibitoroverall survivalprogression-free survivalimmunosenescenceage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qiong Wu Qiuhong Wang Xin Tang Ran Xu Luzhong Zhang Xinming Chen Qun Xue Ziheng Wang Rongfeng Shi Feiran Wang Fei Ju Bo Zhang You Lang Zhou |
spellingShingle |
Qiong Wu Qiuhong Wang Xin Tang Ran Xu Luzhong Zhang Xinming Chen Qun Xue Ziheng Wang Rongfeng Shi Feiran Wang Fei Ju Bo Zhang You Lang Zhou Correlation between patients’ age and cancer immunotherapy efficacy OncoImmunology immune checkpoint inhibitor overall survival progression-free survival immunosenescence age |
author_facet |
Qiong Wu Qiuhong Wang Xin Tang Ran Xu Luzhong Zhang Xinming Chen Qun Xue Ziheng Wang Rongfeng Shi Feiran Wang Fei Ju Bo Zhang You Lang Zhou |
author_sort |
Qiong Wu |
title |
Correlation between patients’ age and cancer immunotherapy efficacy |
title_short |
Correlation between patients’ age and cancer immunotherapy efficacy |
title_full |
Correlation between patients’ age and cancer immunotherapy efficacy |
title_fullStr |
Correlation between patients’ age and cancer immunotherapy efficacy |
title_full_unstemmed |
Correlation between patients’ age and cancer immunotherapy efficacy |
title_sort |
correlation between patients’ age and cancer immunotherapy efficacy |
publisher |
Taylor & Francis Group |
series |
OncoImmunology |
issn |
2162-402X |
publishDate |
2019-04-01 |
description |
Background: Although immunosenescence-induced difference on overall immune function and immune cell subsets between younger and older populations has been well characterized, the potential effect of patients’ age on the efficacy of immune checkpoint inhibitors (ICIs) remains little known. We performed a meta-analysis to investigate whether age differences play a role in cancer immunotherapy efficacy based on a large amount of clinical data. Methods: We conducted a systematic search of PubMed, Embase and MEDLINE for relevant randomized controlled trials. The primary outcome was overall survival (OS) and progression-free survival (PFS) was secondary outcome. The interaction test was used to assess the heterogeneity of HR between younger and older groups. Results: In total, 19 clinical randomized trials involving 11157 patients were included. The pooled HR for OS was 0.73 (95% CI 0.69–0.78) and 0.63 (95% CI 0.52–0.73) for PFS in younger patients receiving ICIs treatments, when compared with younger patients treated with controls. For older patients treated with ICIs, the pooled HR for OS compared with controls was 0.64 (95% CI 0.59–0.69) and 0.66 (95% CI 0.58–0.74) for PFS. The difference on OS efficacy between younger and older patients treated with ICIs was significant (Pheterogeneity = 0.025). Conclusions: Immune checkpoint inhibitors significantly improved OS and PFS in both younger and older patients compared with controls, but the magnitude of benefit was clinically age-dependent. Patients ≥65 y can benefit more from immunotherapy than younger patients. Future research should take age difference into consideration in trials and focus on tolerance and toxicity of ICIs in older patients. |
topic |
immune checkpoint inhibitor overall survival progression-free survival immunosenescence age |
url |
http://dx.doi.org/10.1080/2162402X.2019.1568810 |
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