Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates. However, there is no definitive evidence that this process occurs in mammals. We used fate-mapping an...
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doaj-f033cab0a95b40d08c335803fb249cb82021-05-05T13:18:55ZengeLife Sciences Publications LtdeLife2050-084X2017-03-01610.7554/eLife.18128Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult miceStephanie A Bucks0Brandon C Cox1Brittany A Vlosich2James P Manning3Tot B Nguyen4Jennifer S Stone5https://orcid.org/0000-0002-6742-0590Department of Otolaryngology-Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, United StatesDepartment of Pharmacology, Southern Illinois University School of Medicine, Springfield, United States; Department of Surgery, Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield, United StatesDepartment of Otolaryngology-Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, United StatesDepartment of Otolaryngology-Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, United StatesDepartment of Otolaryngology-Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, United StatesDepartment of Otolaryngology-Head and Neck Surgery, Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, United StatesVestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates. However, there is no definitive evidence that this process occurs in mammals. We used fate-mapping and other methods to demonstrate that utricular type II vestibular hair cells undergo turnover in adult mice under normal conditions. We found that supporting cells phagocytose both type I and II hair cells. Plp1-CreERT2-expressing supporting cells replace type II hair cells. Type I hair cells are not restored by Plp1-CreERT2-expressing supporting cells or by Atoh1-CreERTM-expressing type II hair cells. Destruction of hair cells causes supporting cells to generate 6 times as many type II hair cells compared to normal conditions. These findings expand our understanding of sensorineural plasticity in adult vestibular organs and further elucidate the roles that supporting cells serve during homeostasis and after injury.https://elifesciences.org/articles/18128hair cellsupporting cellturnoverregenerationvestibularutricle |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephanie A Bucks Brandon C Cox Brittany A Vlosich James P Manning Tot B Nguyen Jennifer S Stone |
spellingShingle |
Stephanie A Bucks Brandon C Cox Brittany A Vlosich James P Manning Tot B Nguyen Jennifer S Stone Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice eLife hair cell supporting cell turnover regeneration vestibular utricle |
author_facet |
Stephanie A Bucks Brandon C Cox Brittany A Vlosich James P Manning Tot B Nguyen Jennifer S Stone |
author_sort |
Stephanie A Bucks |
title |
Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice |
title_short |
Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice |
title_full |
Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice |
title_fullStr |
Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice |
title_full_unstemmed |
Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice |
title_sort |
supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2017-03-01 |
description |
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates. However, there is no definitive evidence that this process occurs in mammals. We used fate-mapping and other methods to demonstrate that utricular type II vestibular hair cells undergo turnover in adult mice under normal conditions. We found that supporting cells phagocytose both type I and II hair cells. Plp1-CreERT2-expressing supporting cells replace type II hair cells. Type I hair cells are not restored by Plp1-CreERT2-expressing supporting cells or by Atoh1-CreERTM-expressing type II hair cells. Destruction of hair cells causes supporting cells to generate 6 times as many type II hair cells compared to normal conditions. These findings expand our understanding of sensorineural plasticity in adult vestibular organs and further elucidate the roles that supporting cells serve during homeostasis and after injury. |
topic |
hair cell supporting cell turnover regeneration vestibular utricle |
url |
https://elifesciences.org/articles/18128 |
work_keys_str_mv |
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