Ultrasound assessment of carotid artery elasticity in patients with coronary heart disease and its correlation with plaque stability and platelet function
Objective: To study the ultrasound assessment of carotid artery elasticity in patients with coronary heart disease and its correlation with plaque stability and platelet function. Methods: Patients with stable angina pectoris, patients with unstable angina pectoris and healthy volunteers were sel...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-05-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201709/37.pdf |
Summary: | Objective: To study the ultrasound assessment of carotid artery elasticity in patients
with coronary heart disease and its correlation with plaque stability and platelet function.
Methods: Patients with stable angina pectoris, patients with unstable angina pectoris and
healthy volunteers were selected and included in SAP group, UAP group and control group
respectively. Carotid ultrasonography was conducted to determine single point pulse wave
velocity (PWVβ); serum and peripheral blood samples were collected to determine plaque
stability-related indexes and platelet function-related indexes. Results: Carotid artery PWVβ
level, serum ICTP, MMP1, MMP3, MMP7, CatK, CD62p and CD63 contents as well as
peripheral blood PAR1 and LOX1 expression of SAP group and UAP group were significantly
higher than those of control group, and carotid artery PWVβ level, serum ICTP, MMP1,
MMP3, MMP7, CatK, CD62p and CD63 contents as well as peripheral blood PAR1 and LOX1
expression of UAP group were significantly higher than those of SAP group; peripheral blood
PAR1 and LOX1 expression as well as serum CD62p, CD63, ICTP, MMP1, MMP3, MMP7,
CatK, CD62p and CD63 contents of coronary heart disease patients with high PWVβ levels
were significantly higher than those of coronary heart disease patients with low PWVβ levels.
Conclusion: The carotid artery elasticity ultrasound parameter PWVβ has assessment value
for the plaque stability and platelet function in patients with coronary heart disease angina
pectoris. |
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ISSN: | 1007-1237 1007-1237 |