Ultrasound assessment of carotid artery elasticity in patients with coronary heart disease and its correlation with plaque stability and platelet function

• Main Authors: Xu Yang1, Yun-Yan Duan1, Xue-Mei Zhang2, Hong-Bo Zhao1, Peng Li1
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-05-01
• Series: Journal of Hainan Medical University
• Subjects: Coronary heart disease Carotid atherosclerosis Plaque stability Platelet function
• Online Access: http://www.hnykdxxb.com/PDF/201709/37.pdf

Objective: To study the ultrasound assessment of carotid artery elasticity in patients with coronary heart disease and its correlation with plaque stability and platelet function. Methods: Patients with stable angina pectoris, patients with unstable angina pectoris and healthy volunteers were selected and included in SAP group, UAP group and control group respectively. Carotid ultrasonography was conducted to determine single point pulse wave velocity (PWVβ); serum and peripheral blood samples were collected to determine plaque stability-related indexes and platelet function-related indexes. Results: Carotid artery PWVβ level, serum ICTP, MMP1, MMP3, MMP7, CatK, CD62p and CD63 contents as well as peripheral blood PAR1 and LOX1 expression of SAP group and UAP group were significantly higher than those of control group, and carotid artery PWVβ level, serum ICTP, MMP1, MMP3, MMP7, CatK, CD62p and CD63 contents as well as peripheral blood PAR1 and LOX1 expression of UAP group were significantly higher than those of SAP group; peripheral blood PAR1 and LOX1 expression as well as serum CD62p, CD63, ICTP, MMP1, MMP3, MMP7, CatK, CD62p and CD63 contents of coronary heart disease patients with high PWVβ levels were significantly higher than those of coronary heart disease patients with low PWVβ levels. Conclusion: The carotid artery elasticity ultrasound parameter PWVβ has assessment value for the plaque stability and platelet function in patients with coronary heart disease angina pectoris.