Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats
Objective. In this study, we evaluated changes in bone remodeling in an irradiated rat calvarial defect model according to duration of hyperbaric oxygen therapy. Materials and Methods. The 28 rats were divided into four groups. Radiation of 12 Gy was applied to the skull, and 5-mm critical size defe...
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Online Access: | http://dx.doi.org/10.1155/2019/9051713 |
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doaj-f05ecfa896bc48a8980fb9997c2e50f52020-11-24T22:43:58ZengHindawi LimitedBioMed Research International2314-61332314-61412019-01-01201910.1155/2019/90517139051713Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated RatsKyeong-Mee Park0Changdae Kim1Wonse Park2Young-Bum Park3Moon-Kyu Chung4Sungtae Kim5Department of Advanced General Dentistry, Yonsei University College of Dentistry, Seoul, Republic of KoreaDepartment of Prosthodontics, Yonsei University College of Dentistry, Seoul, Republic of KoreaDepartment of Advanced General Dentistry, Yonsei University College of Dentistry, Seoul, Republic of KoreaDepartment of Prosthodontics, Yonsei University College of Dentistry, Seoul, Republic of KoreaDepartment of Prosthodontics, Yonsei University College of Dentistry, Seoul, Republic of KoreaDepartment of Periodontology, Dental Research Institute, Seoul Nation University School of Dentistry, Seoul, Republic of KoreaObjective. In this study, we evaluated changes in bone remodeling in an irradiated rat calvarial defect model according to duration of hyperbaric oxygen therapy. Materials and Methods. The 28 rats were divided into four groups. Radiation of 12 Gy was applied to the skull, and 5-mm critical size defects were formed on both sides of the skull. Bone grafts were applied to one side of formed defects. From the day after surgery, HBO was applied for 0, 1, and 3 weeks. At 6 weeks after bone graft, experimental sites were removed and analyzed for radiography, histology, and histomorphometry. Results. Micro-CT analysis showed a significant increase in new bone volume in the HBO-3 group, with or without bone graft. When bone grafting was performed, BV, BS, and BS/TV all significantly increased. Histomorphometric analysis showed significant increases in %NBA and %BVN in the HBO-1 and HBO-3 groups, regardless of bone graft. Conclusion. Hyperbaric oxygen therapy was effective for bone regeneration with only 1 week of treatment.http://dx.doi.org/10.1155/2019/9051713 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyeong-Mee Park Changdae Kim Wonse Park Young-Bum Park Moon-Kyu Chung Sungtae Kim |
spellingShingle |
Kyeong-Mee Park Changdae Kim Wonse Park Young-Bum Park Moon-Kyu Chung Sungtae Kim Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats BioMed Research International |
author_facet |
Kyeong-Mee Park Changdae Kim Wonse Park Young-Bum Park Moon-Kyu Chung Sungtae Kim |
author_sort |
Kyeong-Mee Park |
title |
Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats |
title_short |
Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats |
title_full |
Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats |
title_fullStr |
Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats |
title_full_unstemmed |
Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats |
title_sort |
bone regeneration effect of hyperbaric oxygen therapy duration on calvarial defects in irradiated rats |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2019-01-01 |
description |
Objective. In this study, we evaluated changes in bone remodeling in an irradiated rat calvarial defect model according to duration of hyperbaric oxygen therapy. Materials and Methods. The 28 rats were divided into four groups. Radiation of 12 Gy was applied to the skull, and 5-mm critical size defects were formed on both sides of the skull. Bone grafts were applied to one side of formed defects. From the day after surgery, HBO was applied for 0, 1, and 3 weeks. At 6 weeks after bone graft, experimental sites were removed and analyzed for radiography, histology, and histomorphometry. Results. Micro-CT analysis showed a significant increase in new bone volume in the HBO-3 group, with or without bone graft. When bone grafting was performed, BV, BS, and BS/TV all significantly increased. Histomorphometric analysis showed significant increases in %NBA and %BVN in the HBO-1 and HBO-3 groups, regardless of bone graft. Conclusion. Hyperbaric oxygen therapy was effective for bone regeneration with only 1 week of treatment. |
url |
http://dx.doi.org/10.1155/2019/9051713 |
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