Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging
Background: Quantification of cardiac structure and function is essential for diagnostic interpretation and clinical decision making. We sought to establish cardiovascular magnetic resonance (CMR) reference values of left and right ventricular (LV and RV) morphology and function based on a large sam...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-07-01
|
Series: | Frontiers in Cardiovascular Medicine |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.697481/full |
id |
doaj-f067ff06735c48278d35f2e36dfee794 |
---|---|
record_format |
Article |
spelling |
doaj-f067ff06735c48278d35f2e36dfee7942021-07-19T05:07:56ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-07-01810.3389/fcvm.2021.697481697481Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance ImagingZhen Zhang0Qiaozhi Ma1Yiyuan Gao2Lizhen Cao3Chengcheng Zhu4Zhiwei Zhao5Jun Zhao6Linan Zeng7Mingwu Lou8Gerald M. Pohost9Gerald M. Pohost10Kuncheng Li11Kuncheng Li12Post-doctoral Research Center, Department of Radiology, Longgang Central Hospital, Shenzhen Clinical Medical Institute, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Radiology, The Third Medical Centre of Chinese PLA General Hospital, Beijing, ChinaPost-doctoral Research Center, Department of Radiology, Longgang Central Hospital, Shenzhen Clinical Medical Institute, Guangzhou University of Chinese Medicine, Shenzhen, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, University of Washington, Seattle, WA, United StatesZhouxin Medical Imaging and Health Screening Centre, Xiamen, ChinaZhouxin Medical Imaging and Health Screening Centre, Xiamen, ChinaZhouxin Medical Imaging and Health Screening Centre, Xiamen, ChinaPost-doctoral Research Center, Department of Radiology, Longgang Central Hospital, Shenzhen Clinical Medical Institute, Guangzhou University of Chinese Medicine, Shenzhen, ChinaZhouxin Medical Imaging and Health Screening Centre, Xiamen, ChinaKeck School of Medicine, University of Southern California, Los Angeles, CA, United StatesDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaZhouxin Medical Imaging and Health Screening Centre, Xiamen, ChinaBackground: Quantification of cardiac structure and function is essential for diagnostic interpretation and clinical decision making. We sought to establish cardiovascular magnetic resonance (CMR) reference values of left and right ventricular (LV and RV) morphology and function based on a large sample of healthy Chinese adults.Methods: Five hundred fifty validated healthy Chinese adults (aged 21–70 years; 323 men) free of hypertension, diabetes, and obesity were included in this study. All the subjects were stratified by gender (men and women) and age decades. On cine CMR, measurements of biventricular end-diastolic, end-systolic, and stroke volumes (EDV, ESV, and SV), ejection fraction (EF), and end-diastolic LV wall thickness (LVWT) and mass (LVM) were obtained.Results: Men had greater LVEDV (111.6 ± 19.8 vs. 94.6 ± 15.6 ml), LVESV (36.5 ± 9.8 vs. 28.2 ± 7.9 ml), LVM (121.1 ± 19.9 vs. 86.1 ± 14.5 g), global end-diastolic LVWT (8.1 ± 1.1 vs. 6.7 ± 1.0 mm), RVEDV (128.0 ± 23.6 vs. 101.7 ± 17.0 ml), and RVESV (53.5 ± 13.7 vs. 36.8 ± 8.9 ml), while women had greater LVEF (67.5 ± 5.4 vs. 70.4 ± 5.7%) and RVEF (58.5 ± 5.2 vs. 64.0 ± 5.3%) (all p < 0.001). For both men and women, age was negatively correlated with LVEDV (r = −0.31 and r = −0.32), LVESV (r = −0.37 and r = −0.47), RVEDV (r = −0.31 and r = −0.29), and RVESV (r = −0.33 and r = −0.44), while it was positively correlated with LVEF (r = 0.28 and r = 0.43) and RVEF (r = 0.28 and r = 0.41) (all p < 0.001). Aging was associated with increasing global end-diastolic LVWT and LVM/LVEDV in both sexes (all p < 0.001). Older age was associated with increasing LVM only in women (r = 0.36, p < 0.001), not in men (r = 0.05, p = 0.359).Conclusions: We systematically provide age-, sex-, and body size-specific CMR reference values for biventricular morphology and function based on a large sample of healthy Chinese adults. Biventricular structure and function are significantly associated with age and sex.https://www.frontiersin.org/articles/10.3389/fcvm.2021.697481/fullcardiovascular magnetic resonancereference valueleft ventricleright ventricleChinese adults |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhen Zhang Qiaozhi Ma Yiyuan Gao Lizhen Cao Chengcheng Zhu Zhiwei Zhao Jun Zhao Linan Zeng Mingwu Lou Gerald M. Pohost Gerald M. Pohost Kuncheng Li Kuncheng Li |
spellingShingle |
Zhen Zhang Qiaozhi Ma Yiyuan Gao Lizhen Cao Chengcheng Zhu Zhiwei Zhao Jun Zhao Linan Zeng Mingwu Lou Gerald M. Pohost Gerald M. Pohost Kuncheng Li Kuncheng Li Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging Frontiers in Cardiovascular Medicine cardiovascular magnetic resonance reference value left ventricle right ventricle Chinese adults |
author_facet |
Zhen Zhang Qiaozhi Ma Yiyuan Gao Lizhen Cao Chengcheng Zhu Zhiwei Zhao Jun Zhao Linan Zeng Mingwu Lou Gerald M. Pohost Gerald M. Pohost Kuncheng Li Kuncheng Li |
author_sort |
Zhen Zhang |
title |
Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging |
title_short |
Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging |
title_full |
Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging |
title_fullStr |
Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging |
title_full_unstemmed |
Biventricular Morphology and Function Reference Values Derived From a Large Sample of Healthy Chinese Adults by Magnetic Resonance Imaging |
title_sort |
biventricular morphology and function reference values derived from a large sample of healthy chinese adults by magnetic resonance imaging |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2021-07-01 |
description |
Background: Quantification of cardiac structure and function is essential for diagnostic interpretation and clinical decision making. We sought to establish cardiovascular magnetic resonance (CMR) reference values of left and right ventricular (LV and RV) morphology and function based on a large sample of healthy Chinese adults.Methods: Five hundred fifty validated healthy Chinese adults (aged 21–70 years; 323 men) free of hypertension, diabetes, and obesity were included in this study. All the subjects were stratified by gender (men and women) and age decades. On cine CMR, measurements of biventricular end-diastolic, end-systolic, and stroke volumes (EDV, ESV, and SV), ejection fraction (EF), and end-diastolic LV wall thickness (LVWT) and mass (LVM) were obtained.Results: Men had greater LVEDV (111.6 ± 19.8 vs. 94.6 ± 15.6 ml), LVESV (36.5 ± 9.8 vs. 28.2 ± 7.9 ml), LVM (121.1 ± 19.9 vs. 86.1 ± 14.5 g), global end-diastolic LVWT (8.1 ± 1.1 vs. 6.7 ± 1.0 mm), RVEDV (128.0 ± 23.6 vs. 101.7 ± 17.0 ml), and RVESV (53.5 ± 13.7 vs. 36.8 ± 8.9 ml), while women had greater LVEF (67.5 ± 5.4 vs. 70.4 ± 5.7%) and RVEF (58.5 ± 5.2 vs. 64.0 ± 5.3%) (all p < 0.001). For both men and women, age was negatively correlated with LVEDV (r = −0.31 and r = −0.32), LVESV (r = −0.37 and r = −0.47), RVEDV (r = −0.31 and r = −0.29), and RVESV (r = −0.33 and r = −0.44), while it was positively correlated with LVEF (r = 0.28 and r = 0.43) and RVEF (r = 0.28 and r = 0.41) (all p < 0.001). Aging was associated with increasing global end-diastolic LVWT and LVM/LVEDV in both sexes (all p < 0.001). Older age was associated with increasing LVM only in women (r = 0.36, p < 0.001), not in men (r = 0.05, p = 0.359).Conclusions: We systematically provide age-, sex-, and body size-specific CMR reference values for biventricular morphology and function based on a large sample of healthy Chinese adults. Biventricular structure and function are significantly associated with age and sex. |
topic |
cardiovascular magnetic resonance reference value left ventricle right ventricle Chinese adults |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2021.697481/full |
work_keys_str_mv |
AT zhenzhang biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT qiaozhima biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT yiyuangao biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT lizhencao biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT chengchengzhu biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT zhiweizhao biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT junzhao biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT linanzeng biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT mingwulou biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT geraldmpohost biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT geraldmpohost biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT kunchengli biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging AT kunchengli biventricularmorphologyandfunctionreferencevaluesderivedfromalargesampleofhealthychineseadultsbymagneticresonanceimaging |
_version_ |
1721295386256080896 |