Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

Abstract Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors. Deletion or inhibition of the TRPM8 channel was found to p...

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Bibliographic Details
Main Authors: Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang, Christophe Altier
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Molecular Brain
Subjects:
Transient receptor potential channel subfamily M (melastatin) member 8 (TRPM8)
Mu opioid receptor (MOR)
Morphine
Protein kinase C beta (PKCβ)
Dorsal root ganglia (DRG) neurons
Cold hyperalgesia
Online Access:http://link.springer.com/article/10.1186/s13041-020-00599-0

Internet

http://link.springer.com/article/10.1186/s13041-020-00599-0

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