High flavivirus structural plasticity demonstrated by a non-spherical morphological variant

Dengue (DENV) and Zika (ZIKV) viruses normally display as smooth spherical particles, while DENV can also become bumpy-surfaced, resulting in immune evasion. Here, Morrone et al. report DENV and ZIKV infectious club-shaped particles (clubSP) that display distinct antibody binding properties.

Bibliographic Details
Main Authors:	Seamus R. Morrone, Valerie S. Y. Chew, Xin-Ni Lim, Thiam-Seng Ng, Victor A. Kostyuchenko, Shuijun Zhang, Melissa Wirawan, Pau-Ling Chew, Jaime Lee, Joanne L. Tan, Jiaqi Wang, Ter Yong Tan, Jian Shi, Gavin Screaton, Marc C. Morais, Shee-Mei Lok
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16925-y

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spelling	doaj-f08301c050d845ffa06cdd50556aeafb2021-06-20T11:14:41ZengNature Publishing GroupNature Communications2041-17232020-06-0111111010.1038/s41467-020-16925-yHigh flavivirus structural plasticity demonstrated by a non-spherical morphological variantSeamus R. Morrone0Valerie S. Y. Chew1Xin-Ni Lim2Thiam-Seng Ng3Victor A. Kostyuchenko4Shuijun Zhang5Melissa Wirawan6Pau-Ling Chew7Jaime Lee8Joanne L. Tan9Jiaqi Wang10Ter Yong Tan11Jian Shi12Gavin Screaton13Marc C. Morais14Shee-Mei Lok15Program in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolCentre for BioImaging Sciences, National University of SingaporeMedical Sciences Division, University of OxfordSealy Center for Structural Biology and Molecular Biophysics, Department of Biochemistry and Molecular Biology, University of Texas Medical BranchProgram in Emerging Infectious Diseases, Duke-NUS Medical SchoolDengue (DENV) and Zika (ZIKV) viruses normally display as smooth spherical particles, while DENV can also become bumpy-surfaced, resulting in immune evasion. Here, Morrone et al. report DENV and ZIKV infectious club-shaped particles (clubSP) that display distinct antibody binding properties.https://doi.org/10.1038/s41467-020-16925-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Seamus R. Morrone Valerie S. Y. Chew Xin-Ni Lim Thiam-Seng Ng Victor A. Kostyuchenko Shuijun Zhang Melissa Wirawan Pau-Ling Chew Jaime Lee Joanne L. Tan Jiaqi Wang Ter Yong Tan Jian Shi Gavin Screaton Marc C. Morais Shee-Mei Lok
spellingShingle	Seamus R. Morrone Valerie S. Y. Chew Xin-Ni Lim Thiam-Seng Ng Victor A. Kostyuchenko Shuijun Zhang Melissa Wirawan Pau-Ling Chew Jaime Lee Joanne L. Tan Jiaqi Wang Ter Yong Tan Jian Shi Gavin Screaton Marc C. Morais Shee-Mei Lok High flavivirus structural plasticity demonstrated by a non-spherical morphological variant Nature Communications
author_facet	Seamus R. Morrone Valerie S. Y. Chew Xin-Ni Lim Thiam-Seng Ng Victor A. Kostyuchenko Shuijun Zhang Melissa Wirawan Pau-Ling Chew Jaime Lee Joanne L. Tan Jiaqi Wang Ter Yong Tan Jian Shi Gavin Screaton Marc C. Morais Shee-Mei Lok
author_sort	Seamus R. Morrone
title	High flavivirus structural plasticity demonstrated by a non-spherical morphological variant
title_short	High flavivirus structural plasticity demonstrated by a non-spherical morphological variant
title_full	High flavivirus structural plasticity demonstrated by a non-spherical morphological variant
title_fullStr	High flavivirus structural plasticity demonstrated by a non-spherical morphological variant
title_full_unstemmed	High flavivirus structural plasticity demonstrated by a non-spherical morphological variant
title_sort	high flavivirus structural plasticity demonstrated by a non-spherical morphological variant
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Dengue (DENV) and Zika (ZIKV) viruses normally display as smooth spherical particles, while DENV can also become bumpy-surfaced, resulting in immune evasion. Here, Morrone et al. report DENV and ZIKV infectious club-shaped particles (clubSP) that display distinct antibody binding properties.
url	https://doi.org/10.1038/s41467-020-16925-y
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High flavivirus structural plasticity demonstrated by a non-spherical morphological variant

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