Spina Bifida Defying Folic Acid Supplementation
Pre-conceptional supplementation of folic acid is well known to reduce the incidence of spina bifida. But Athena is frequently perplexed to see this anomaly occurring despite folate supplementation. In a largest Canadian study, De Wal et al [1] screened 1.9 million live births to study the effect of...
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| Format: | Article |
| Language: | English |
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EL-Med-Pub
2012-07-01
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| Series: | Journal of Neonatal Surgery |
| Subjects: | |
| Online Access: | http://jneonatalsurg.com/documents/vol-1/pdf/jns-1-65.pdf |
| Summary: | Pre-conceptional supplementation of folic acid is well known to reduce the incidence of spina bifida. But Athena is frequently perplexed to see this anomaly occurring despite folate supplementation. In a largest Canadian study, De Wal et al [1] screened 1.9 million live births to study the effect of mass fortification. On comparing pre and post fortification periods they noted only 46% reduction in the incidence of neural tube defects (NTD). What happens to the remaining 54%? Why do they defy “folic acid” logics? Recently several publications have shed more light on this intriguing question. |
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| ISSN: | 2226-0439 |