A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells
The removal of mRNA transcript poly(A) tails by 3′→5′ exonucleases is the rate-limiting step in mRNA decay in eukaryotes. Known cellular deadenylases are the CCR4-NOT and PAN complexes, and poly(A)-specific ribonuclease (PARN). The physiological roles and regulation for PARN is beginning to be eluci...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2017-02-01
|
Series: | Biology Open |
Subjects: | |
Online Access: | http://bio.biologists.org/content/6/2/176 |