Zinc-finger nuclease mediated disruption of <it>Rag1</it> in the LEW/Ztm rat

Zinc-finger nuclease mediated disruption of <it>Rag1</it> in the LEW/Ztm rat

<p>Abstract</p> <p>Background</p> <p>Engineered zinc-finger nucleases (ZFN) represented an innovative method for the genome manipulation in vertebrates. ZFN introduced targeted DNA double strand breaks (DSB) and initiated non-homologous end joining (NHEJ) after pronucle...

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Bibliographic Details
Main Authors: Zschemisch Nils-Holger, Glage Silke, Wedekind Dirk, Weinstein Edward J, Cui Xiaoxia, Dorsch Martina, Hedrich Hans-Jürgen
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Immunology
Subjects:
<it>Rag1</it>
Zinc-finger nucleases
Rat
Lymphocytes
Natural killer cells
Hypoplastic thymus
Online Access:http://www.biomedcentral.com/1471-2172/13/60

Internet

http://www.biomedcentral.com/1471-2172/13/60

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