Long-acting protein drugs for the treatment of ocular diseases
Retinal vascular disease treatments involve frequent pharmacological intraocular administrations. Here the authors present a method to increase the half-life of injected drugs by fusing these to a hyaluronan-binding peptide, which might lead to less frequent retinal disease treatments.
Main Authors: | Joy G. Ghosh, Andrew A. Nguyen, Chad E. Bigelow, Stephen Poor, Yubin Qiu, Nalini Rangaswamy, Richard Ornberg, Brittany Jackson, Howard Mak, Tucker Ezell, Vania Kenanova, Elisa de la Cruz, Ana Carrion, Bijan Etemad-Gilbertson, Roxana Garcia Caro, Kan Zhu, Vinney George, Jirong Bai, Radhika Sharma-Nahar, Siyuan Shen, Yiqin Wang, Kulandayan K. Subramanian, Elizabeth Fassbender, Michael Maker, Shawn Hanks, Joanna Vrouvlianis, Barrett Leehy, Debby Long, Melissa Prentiss, Viral Kansara, Bruce Jaffee, Thaddeus P. Dryja, Michael Roguska |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-03-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms14837 |
Similar Items
-
AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice
by: Vivian W Choi, et al.
Published: (2015-01-01) -
Dissection of the telomere complex CST in Arabidopsis thaliana
by: Leehy, Katherine
Published: (2013) -
Ekonomiczny aspekt funkcjonowania zakładu rzemieślniczego w Krakowie pod koniec XVI i w pierwszej połowie XVII wieku na przykładzie przedsiębiorstwa piwowarsko-karczmarskiego
by: Sławomir Dryja
Published: (2021-07-01) -
Kompetencje kreacyjne biskupa diecezjalnego w wykonywaniu władzy sądowniczej
by: Dominik Dryja
Published: (2017-12-01) -
Suprachoroidal Delivery of Small Molecules, Nanoparticles, Gene and Cell Therapies for Ocular Diseases
by: Chen-rei Wan, et al.
Published: (2021-02-01)