Oral supplementation with ginseng polysaccharide promotes food intake in mice

• Main Authors: Jiawen Wang, Yongxiang Li, Pei Luo, Yuhuang Chen, Qianyun Xi, Hanyu Wu, Weijie Zhao, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Yongliang Zhang, Qingyan Jiang, Lina Wang
• Format: Article
• Language: English
• Published: Wiley 2019-09-01
• Series: Brain and Behavior
• Subjects: blood glucose; feeding behavior; hypothalamus; panax; polysaccharides
• Online Access: https://doi.org/10.1002/brb3.1340

Abstract Introduction Ginseng polysaccharide (GPS, same as Panax polysaccharide) is a kind of polysaccharide extracted from ginseng. It has been reported that GPS has the ability to activate innate immunity, regulates blood sugar balance, and improves antioxidant capacity, but the effect on feeding behavior and its mechanism remains unclear. Method To investigate the possible effect of GPS on feeding behavior of animals, mice were supplied with GPS in water, and food intake, hedonic feeding behavior, anxiety‐like behavior, expression of appetite‐regulation peptides in the central nervous system and glucose‐related hormone levels in the serum of mice were measured. Results Ginseng polysaccharide significantly increased the average daily food intake in mice and promoted hedonic eating behavior. Meanwhile, the levels of serum glucose and glucagon were significantly reduced by GPS, and GPS promoted hypothalamic neuropeptide Y expression, inhibited proopiomelanocortin (POMC) expression, and reduced dopamine D1 receptor (DRD1) levels in the midbrain. We also found that the anxiety level of mice was significantly lower after GPS intake. In conclusion, oral supplementation with GPS promoted food intake in mice, most likely through the regulation of circulating glucose levels.