Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow.
Consistent resting brain activity patterns have been repeatedly demonstrated using measures derived from resting BOLD fMRI data. While those metrics are presumed to reflect underlying spontaneous brain activity (SBA), it is challenging to prove that association because resting BOLD fMRI metrics are...
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doaj-f0bea1af0d7b4d2089735bd7f9506b782020-11-25T02:32:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4455610.1371/journal.pone.0044556Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow.Zhengjun LiYisheng ZhuAnna Rose ChildressJohn A DetreZe WangConsistent resting brain activity patterns have been repeatedly demonstrated using measures derived from resting BOLD fMRI data. While those metrics are presumed to reflect underlying spontaneous brain activity (SBA), it is challenging to prove that association because resting BOLD fMRI metrics are purely model-free and scale-free variables. Cerebral blood flow (CBF) is typically closely coupled to brain metabolism and is used as a surrogate marker for quantifying regional brain function, including resting function. Assessing the correlations between resting BOLD fMRI measures and CBF correlation should provide a means of linking of those measures to the underlying SBA, and a means to quantify those scale-free measures. The purpose of this paper was to examine the CBF correlations of 3 widely used neuroimaging-based SBA measures, including seed-region based functional connectivity (FC), regional homogeneity (ReHo), and amplitude of low frequency fluctuation (ALFF). Test-retest data were acquired to check the stability of potential correlations across time. Reproducible posterior cingulate cortex (PCC) FC vs regional CBF correlations were found in much of the default mode network and visual cortex. Dorsal anterior cingulate cortex (ACC) FC vs CBF correlations were consistently found in bilateral prefrontal cortex. Both ReHo and ALFF were found to be reliably correlated with CBF in most of brain cortex. None of the assessed SBA measures was correlated with whole brain mean CBF. These findings suggest that resting BOLD fMRI-derived measures are coupled with regional CBF and are therefore linked to regional SBA.http://europepmc.org/articles/PMC3448607?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhengjun Li Yisheng Zhu Anna Rose Childress John A Detre Ze Wang |
spellingShingle |
Zhengjun Li Yisheng Zhu Anna Rose Childress John A Detre Ze Wang Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow. PLoS ONE |
author_facet |
Zhengjun Li Yisheng Zhu Anna Rose Childress John A Detre Ze Wang |
author_sort |
Zhengjun Li |
title |
Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow. |
title_short |
Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow. |
title_full |
Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow. |
title_fullStr |
Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow. |
title_full_unstemmed |
Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow. |
title_sort |
relations between bold fmri-derived resting brain activity and cerebral blood flow. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
Consistent resting brain activity patterns have been repeatedly demonstrated using measures derived from resting BOLD fMRI data. While those metrics are presumed to reflect underlying spontaneous brain activity (SBA), it is challenging to prove that association because resting BOLD fMRI metrics are purely model-free and scale-free variables. Cerebral blood flow (CBF) is typically closely coupled to brain metabolism and is used as a surrogate marker for quantifying regional brain function, including resting function. Assessing the correlations between resting BOLD fMRI measures and CBF correlation should provide a means of linking of those measures to the underlying SBA, and a means to quantify those scale-free measures. The purpose of this paper was to examine the CBF correlations of 3 widely used neuroimaging-based SBA measures, including seed-region based functional connectivity (FC), regional homogeneity (ReHo), and amplitude of low frequency fluctuation (ALFF). Test-retest data were acquired to check the stability of potential correlations across time. Reproducible posterior cingulate cortex (PCC) FC vs regional CBF correlations were found in much of the default mode network and visual cortex. Dorsal anterior cingulate cortex (ACC) FC vs CBF correlations were consistently found in bilateral prefrontal cortex. Both ReHo and ALFF were found to be reliably correlated with CBF in most of brain cortex. None of the assessed SBA measures was correlated with whole brain mean CBF. These findings suggest that resting BOLD fMRI-derived measures are coupled with regional CBF and are therefore linked to regional SBA. |
url |
http://europepmc.org/articles/PMC3448607?pdf=render |
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