Antimony(V) and Bismuth(V) Complexes of Lapachol: Synthesis, Crystal Structure and Cytotoxic Activity

Antimony(V) and Bismuth(V) Complexes of Lapachol: Synthesis, Crystal Structure and Cytotoxic Activity

Antimony(V) and bismuth(V) complexes of lapachol have been synthesized by the reaction of Ph3SbCl2 or Ph3BiCl2 with lapachol (Lp) and characterized by several physicochemical techniques such as IR, and NMR spectroscopy and X-ray crystallography. The compounds contain six-coordinated antimony and bis...

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Bibliographic Details
Main Authors: Cynthia Demicheli, Carlos A. de Simone, Frédéric Frézard, Eufrânio N. da Silva Júnior, Cláudio L. Donnici, Elene C. Pereira-Maia, Ludmila G. de Oliveira, Meiriane M. Silva, Flávia C. S. de Paula
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:Molecules
Subjects:
antimony(V) complex
bismuth(V) complex
lapachol
cytotoxicity
cancer
Online Access:http://www.mdpi.com/1420-3049/16/12/10314/
Description
Summary:Antimony(V) and bismuth(V) complexes of lapachol have been synthesized by the reaction of Ph3SbCl2 or Ph3BiCl2 with lapachol (Lp) and characterized by several physicochemical techniques such as IR, and NMR spectroscopy and X-ray crystallography. The compounds contain six-coordinated antimony and bismuth atoms. The antimony(V) complex is a monomeric derivative, (Lp)(Ph3Sb)OH, and the bismuth(V) complex is a dinuclear compound bridged by an oxygen atom, (Lp)2(Ph3Bi)2O. Both compounds inhibited the growth of a chronic myelogenous leukemia cell line and the complex of Bi(V) was about five times more active than free lapachol. This work provides a rare example of an organo-Bi(V) complex showing significant cytotoxic activity.
ISSN:1420-3049

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