Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformation
Abstract The purpose of this retrospective study was to investigate the role in staging and prognostic value of pretherapeutic fluorine-18-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed tomography (CT) in patients with gastric mucosa-associated lymphoid tissue (MALT) lymph...
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2021-04-01
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doaj-f0d49ff5149c42b7a64ed113cf30778c2021-05-02T11:37:11ZengNature Publishing GroupScientific Reports2045-23222021-04-0111111210.1038/s41598-021-88815-2Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformationYong-Jin Park0Seung Hyup Hyun1Seung Hwan Moon2Kyung-Han Lee3Byung Hoon Min4Jun Haeng Lee5Won Seog Kim6Seok Jin Kim7Joon Young Choi8Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDivision of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract The purpose of this retrospective study was to investigate the role in staging and prognostic value of pretherapeutic fluorine-18-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed tomography (CT) in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma without high-grade transformation (HT). We retrospectively reviewed 115 consecutive patients with histopathologically confirmed gastric MALT lymphoma without HT who underwent pretherapeutic F-18 FDG PET/CT. Kaplan–Meier and Cox proportional-hazards regression analyses were used to identify independent prognostic factors for disease free survival (DFS) among 13 clinical parameters and three PET parameters. In two of 115 patients (1.7%), the clinical stage appeared higher according to F-18 FDG PET/CT. In univariate analysis, Helicobacter pylori (HP) infection (P = 0.023), treatment modality (P < 0.001), and stage including PET/CT (P = 0.015) were significant prognostic factors for DFS. In multivariate analysis, only treatment modality was an independent prognostic factor (P = 0.003). In conclusion, F-18 FDG PET/CT played an important role in enabling upstaging of patients with gastric MALT lymphoma without HT. F-18 FDG PET/CT may have a prognostic role in gastric MALT lymphoma without HT by contributing to better staging.https://doi.org/10.1038/s41598-021-88815-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong-Jin Park Seung Hyup Hyun Seung Hwan Moon Kyung-Han Lee Byung Hoon Min Jun Haeng Lee Won Seog Kim Seok Jin Kim Joon Young Choi |
spellingShingle |
Yong-Jin Park Seung Hyup Hyun Seung Hwan Moon Kyung-Han Lee Byung Hoon Min Jun Haeng Lee Won Seog Kim Seok Jin Kim Joon Young Choi Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformation Scientific Reports |
author_facet |
Yong-Jin Park Seung Hyup Hyun Seung Hwan Moon Kyung-Han Lee Byung Hoon Min Jun Haeng Lee Won Seog Kim Seok Jin Kim Joon Young Choi |
author_sort |
Yong-Jin Park |
title |
Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformation |
title_short |
Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformation |
title_full |
Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformation |
title_fullStr |
Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformation |
title_full_unstemmed |
Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformation |
title_sort |
role in staging and prognostic value of pretherapeutic f-18 fdg pet/ct in patients with gastric malt lymphoma without high-grade transformation |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-04-01 |
description |
Abstract The purpose of this retrospective study was to investigate the role in staging and prognostic value of pretherapeutic fluorine-18-fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed tomography (CT) in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma without high-grade transformation (HT). We retrospectively reviewed 115 consecutive patients with histopathologically confirmed gastric MALT lymphoma without HT who underwent pretherapeutic F-18 FDG PET/CT. Kaplan–Meier and Cox proportional-hazards regression analyses were used to identify independent prognostic factors for disease free survival (DFS) among 13 clinical parameters and three PET parameters. In two of 115 patients (1.7%), the clinical stage appeared higher according to F-18 FDG PET/CT. In univariate analysis, Helicobacter pylori (HP) infection (P = 0.023), treatment modality (P < 0.001), and stage including PET/CT (P = 0.015) were significant prognostic factors for DFS. In multivariate analysis, only treatment modality was an independent prognostic factor (P = 0.003). In conclusion, F-18 FDG PET/CT played an important role in enabling upstaging of patients with gastric MALT lymphoma without HT. F-18 FDG PET/CT may have a prognostic role in gastric MALT lymphoma without HT by contributing to better staging. |
url |
https://doi.org/10.1038/s41598-021-88815-2 |
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