RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers
RNA editing is a widespread post-transcriptional mechanism that confers specific and reproducible nucleotide changes in selected RNA transcripts and plays a critical role in many human cancers. However, little is known about how RNA editing operates in non-small-cell lung cancers. Here, we measured...
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doaj-f0dd4db973b04cb2b59eb99761acf3fa2021-05-02T19:21:42ZengIOS PressTumor Biology1423-03802017-08-013910.1177/1010428317700001RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancersXueda Hu0Jingyi Chen1Xiaoshun Shi2Fenglan Feng3King Wai Lau4Yaoqi Chen5Yusong Chen6Long Jiang7Fei Cui8Yalei Zhang9Xin Xu10Jin Li11Biodynamic Optical Imaging Center (BIOPIC), College of Life Sciences, Peking University, Beijing, P.R. ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaWolfson Institute of Preventive Medicine, Queen Mary University of London, London, UKState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. ChinaRNA editing is a widespread post-transcriptional mechanism that confers specific and reproducible nucleotide changes in selected RNA transcripts and plays a critical role in many human cancers. However, little is known about how RNA editing operates in non-small-cell lung cancers. Here, we measured the sequence and expression level of genes of antizyme inhibitor 1 and adenosine deaminase acting on RNA family in 30 non-small-cell lung cancer patient samples and 13 cell lines and revealed RNA editing S367G in antizyme inhibitor 1 is a high-frequent molecular events. We determined overexpression of antizyme inhibitor 1 with RNA editing, implying the oncogenic function of this alteration. We also detected the association of adenosine deaminase acting on RNA overexpression with RNA editing occurred in antizyme inhibitor 1 . Furthermore, the RNA editing could cause a cytoplasmic-to-nuclear translocation of antizyme inhibitor 1 protein and conferred the malignant phenotype of non-small-cell lung cancer cells. The in vivo experiment confirmed that this RNA editing confers higher capacity of tumor migration as well. In conclusion, antizyme inhibitor 1 RNA editing and its involvement in tumorigenesis of non-small-cell lung cancer pave a new way for potential clinical management of non-small-cell lung cancer.https://doi.org/10.1177/1010428317700001 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xueda Hu Jingyi Chen Xiaoshun Shi Fenglan Feng King Wai Lau Yaoqi Chen Yusong Chen Long Jiang Fei Cui Yalei Zhang Xin Xu Jin Li |
spellingShingle |
Xueda Hu Jingyi Chen Xiaoshun Shi Fenglan Feng King Wai Lau Yaoqi Chen Yusong Chen Long Jiang Fei Cui Yalei Zhang Xin Xu Jin Li RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers Tumor Biology |
author_facet |
Xueda Hu Jingyi Chen Xiaoshun Shi Fenglan Feng King Wai Lau Yaoqi Chen Yusong Chen Long Jiang Fei Cui Yalei Zhang Xin Xu Jin Li |
author_sort |
Xueda Hu |
title |
RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers |
title_short |
RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers |
title_full |
RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers |
title_fullStr |
RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers |
title_full_unstemmed |
RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers |
title_sort |
rna editing of azin1 induces the malignant progression of non-small-cell lung cancers |
publisher |
IOS Press |
series |
Tumor Biology |
issn |
1423-0380 |
publishDate |
2017-08-01 |
description |
RNA editing is a widespread post-transcriptional mechanism that confers specific and reproducible nucleotide changes in selected RNA transcripts and plays a critical role in many human cancers. However, little is known about how RNA editing operates in non-small-cell lung cancers. Here, we measured the sequence and expression level of genes of antizyme inhibitor 1 and adenosine deaminase acting on RNA family in 30 non-small-cell lung cancer patient samples and 13 cell lines and revealed RNA editing S367G in antizyme inhibitor 1 is a high-frequent molecular events. We determined overexpression of antizyme inhibitor 1 with RNA editing, implying the oncogenic function of this alteration. We also detected the association of adenosine deaminase acting on RNA overexpression with RNA editing occurred in antizyme inhibitor 1 . Furthermore, the RNA editing could cause a cytoplasmic-to-nuclear translocation of antizyme inhibitor 1 protein and conferred the malignant phenotype of non-small-cell lung cancer cells. The in vivo experiment confirmed that this RNA editing confers higher capacity of tumor migration as well. In conclusion, antizyme inhibitor 1 RNA editing and its involvement in tumorigenesis of non-small-cell lung cancer pave a new way for potential clinical management of non-small-cell lung cancer. |
url |
https://doi.org/10.1177/1010428317700001 |
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