Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement
Purpose: To report the results of topical interferon alpha-2b (IFNα2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360° limbal involvement. Methods: In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360° limbal involvement r...
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doaj-f10456d1afd8451891ea4447776c89682020-11-25T01:54:28ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2014-01-019442342610.4103/2008-322X.150811Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvementSiamak Zarei-GhanavatiReza AlizadehSophie X DengPurpose: To report the results of topical interferon alpha-2b (IFNα2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360° limbal involvement. Methods: In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360° limbal involvement received topical IFNα2b (3 million IU/ml, 4 times daily) and were followed from 8 to 12 months. Outcome measures included resolution of the lesion, relief of symptoms, systemic and ocular side effects, and recurrence rate. Results: Five patients including 4 primary OSSNs and one recurrent OSSN received topical interferon alpha-2b. The mean age was 60.2 (range: 52-73) years and mean follow up duration was 10.2 months. Clinical resolution of the tumor occurred in all cases 2 months after initiation of treatment and no patient developed ocular or systemic complications. No recurrence of OSSN developed during the follow up period. Conclusion: Topical recombinant IFNα2b appears to be an effective alternative treatment for OSSN with 360° limbal involvement. This approach precludes the high risk of limbal stem cell deficiency which results from surgical excision or topical chemotherapeutic agents.http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=423;epage=426;aulast=Zarei-GhanavatiConjunctival Intraepithelial Neoplasia; Interferon Alpha-2b; Ocular Surface Squamous Neoplasia; Ocular Surface Squamous Neoplasia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siamak Zarei-Ghanavati Reza Alizadeh Sophie X Deng |
spellingShingle |
Siamak Zarei-Ghanavati Reza Alizadeh Sophie X Deng Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement Journal of Ophthalmic & Vision Research Conjunctival Intraepithelial Neoplasia; Interferon Alpha-2b; Ocular Surface Squamous Neoplasia; Ocular Surface Squamous Neoplasia |
author_facet |
Siamak Zarei-Ghanavati Reza Alizadeh Sophie X Deng |
author_sort |
Siamak Zarei-Ghanavati |
title |
Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
title_short |
Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
title_full |
Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
title_fullStr |
Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
title_full_unstemmed |
Topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
title_sort |
topical interferon alpha-2b for treatment of noninvasive ocular surface squamous neoplasia with 360° limbal involvement |
publisher |
Knowledge E |
series |
Journal of Ophthalmic & Vision Research |
issn |
2008-322X |
publishDate |
2014-01-01 |
description |
Purpose: To report the results of topical interferon alpha-2b (IFNα2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360° limbal involvement.
Methods: In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360° limbal involvement received topical IFNα2b (3 million IU/ml, 4 times daily) and were followed from 8 to 12 months. Outcome measures included resolution of the lesion, relief of symptoms, systemic and ocular side effects, and recurrence rate.
Results: Five patients including 4 primary OSSNs and one recurrent OSSN received topical interferon alpha-2b. The mean age was 60.2 (range: 52-73) years and mean follow up duration was 10.2 months. Clinical resolution of the tumor occurred in all cases 2 months after initiation of treatment and no patient developed ocular or systemic complications. No recurrence of OSSN developed during the follow up period.
Conclusion: Topical recombinant IFNα2b appears to be an effective alternative treatment for OSSN with 360° limbal involvement. This approach precludes the high risk of limbal stem cell deficiency which results from surgical excision or topical chemotherapeutic agents. |
topic |
Conjunctival Intraepithelial Neoplasia; Interferon Alpha-2b; Ocular Surface Squamous Neoplasia; Ocular Surface Squamous Neoplasia |
url |
http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=4;spage=423;epage=426;aulast=Zarei-Ghanavati |
work_keys_str_mv |
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