Resolving the Paradox of Colon Cancer Through the Integration of Genetics, Immunology, and the Microbiota
While colorectal cancers (CRC) are paradigmatic tumors invaded by effector memory lymphocytes, the mechanisms accounting for the relative resistance of MSI negative CRC to immunogenic cell death mediated by oxaliplatin and immune checkpoint inhibitors has remained an open conundrum. Here, we propose...
Main Authors: | Marine Fidelle, Satoru Yonekura, Marion Picard, Alexandria Cogdill, Antoine Hollebecque, Maria Paula Roberti, Laurence Zitvogel |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-12-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.600886/full |
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