Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7

Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7

Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with the p. R663H (c. 1988 G > A) mutation in MYH7. The generated hiPSC line had n...

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Main Authors: Xiaowei Li, Yangyang Liu, Feifei Liu, Xiaojuan Wang, Mengduan Liu, Wenting Du, Jing Zhao, Mengyu Wang, Liang Hu, Chuchu Wang, Wanrong Fu, Jianzeng Dong, Xiaoyan Zhao
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120300015
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spelling doaj-f10934c4e1594cdfbbc13539e5f86c9c2020-11-25T00:35:53ZengElsevierStem Cell Research1873-50612020-03-0143Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7Xiaowei Li0Yangyang Liu1Feifei Liu2Xiaojuan Wang3Mengduan Liu4Wenting Du5Jing Zhao6Mengyu Wang7Liang Hu8Chuchu Wang9Wanrong Fu10Jianzeng Dong11Xiaoyan Zhao12Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou, 450001, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, No. 2 Beijing Anzhen Road, Chaoyang District, Beijing 100029, China; Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China; Department of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China; Correspondence author at: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with the p. R663H (c. 1988 G > A) mutation in MYH7. The generated hiPSC line had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vivo.http://www.sciencedirect.com/science/article/pii/S1873506120300015
collection DOAJ
language English
format Article
sources DOAJ
author Xiaowei Li
Yangyang Liu
Feifei Liu
Xiaojuan Wang
Mengduan Liu
Wenting Du
Jing Zhao
Mengyu Wang
Liang Hu
Chuchu Wang
Wanrong Fu
Jianzeng Dong
Xiaoyan Zhao
spellingShingle Xiaowei Li
Yangyang Liu
Feifei Liu
Xiaojuan Wang
Mengduan Liu
Wenting Du
Jing Zhao
Mengyu Wang
Liang Hu
Chuchu Wang
Wanrong Fu
Jianzeng Dong
Xiaoyan Zhao
Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7
Stem Cell Research
author_facet Xiaowei Li
Yangyang Liu
Feifei Liu
Xiaojuan Wang
Mengduan Liu
Wenting Du
Jing Zhao
Mengyu Wang
Liang Hu
Chuchu Wang
Wanrong Fu
Jianzeng Dong
Xiaoyan Zhao
author_sort Xiaowei Li
title Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7
title_short Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7
title_full Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7
title_fullStr Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7
title_full_unstemmed Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7
title_sort generation of a hipsc line zzuneui007-a from a patient with hypertrophic cardiomyopathy caused by mutation in myh7
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2020-03-01
description Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with the p. R663H (c. 1988 G > A) mutation in MYH7. The generated hiPSC line had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vivo.
url http://www.sciencedirect.com/science/article/pii/S1873506120300015
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