Aging-related tumor associated fibroblasts changes could worsen the prognosis of GBM patients

• Main Authors: Hongwang Song, Xiaojun Fu, Chenxing Wu, Shouwei Li
• Format: Article
• Language: English
• Published: BMC 2020-10-01
• Series: Cancer Cell International
• Subjects: Glioblastoma; Tumor heterogeneity; Tumor microenvironment; Tumor associated fibroblasts; Epithelial mesenchymal transition
• Online Access: http://link.springer.com/article/10.1186/s12935-020-01571-7

Abstract Background Glioblastoma multiforme (GBM) is the most malignant tumor in human brain, with highly heterogeneity among different patients. Age could function as an incidence and prognosis risk factor for many tumors. Method A series of bioinformatic experiments were conducted to evaluate the differences of incidence, differential expressed genes, enriched pathways with the data from Surveillance, Epidemiology, and End Results (SEER) program, the cancer genome atlas (TCGA) and Chinese glioma genome atlas (CGGA) project. Results We discovered in our present study that distinct difference of incidence and prognosis of different aged GBM patients. By a series of bioinformatic method, we found that the tumor associated fibroblasts (TAFs) was the most crucial tumor microenvironment (TME) component that led to this phenomenon. Epithelial-mesenchymal transition (EMT) could be the mechanism by which TAFs regulate the progression of GBM. Conclusion We have proposed a close correlation between age and GBM incidence and prognosis, and propose the underlying mechanism behind this correlation by mining different databases, which laid the foundation for future research.