Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation.
Paired associative stimulation (PASLTP) of the human primary motor cortex (M1) can induce LTP-like plasticity by increasing corticospinal excitability beyond the stimulation period. Previous studies showed that two consecutive PASLTP protocols interact by homeostatic metaplasticity, but animal exper...
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doaj-f11666b98c4f43b284bc35384cb894662020-11-24T21:26:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e013102010.1371/journal.pone.0131020Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation.Florian Müller-DahlhausCaroline LückeMing-Kuei LuNoritoshi AraiAnna FuhlEva HerrmannUlf ZiemannPaired associative stimulation (PASLTP) of the human primary motor cortex (M1) can induce LTP-like plasticity by increasing corticospinal excitability beyond the stimulation period. Previous studies showed that two consecutive PASLTP protocols interact by homeostatic metaplasticity, but animal experiments provided evidence that LTP can be augmented by repeated stimulation protocols spaced by ~30 min. Here we tested in twelve healthy selected PASLTP responders the possibility that LTP-like plasticity can be augmented in the human M1 by systematically varying the interval between two consecutive PASLTP protocols. The first PASLTP protocol (PAS1) induced strong LTP-like plasticity lasting for 30-60 min. The effect of a second identical PASLTP protocol (PAS2) critically depended on the time between PAS1 and PAS2. At 10 min, PAS2 prolonged the PAS1-induced LTP-like plasticity. At 30 min, PAS2 augmented the LTP-like plasticity induced by PAS1, by increasing both magnitude and duration. At 60 min and 180 min, PAS2 had no effect on corticospinal excitability. The cumulative LTP-like plasticity after PAS1 and PAS2 at 30 min exceeded significantly the effect of PAS1 alone, and the cumulative PAS1 and PAS2 effects at 60 min and 180 min. In summary, consecutive PASLTP protocols interact in human M1 in a time-dependent manner. If spaced by 30 min, two consecutive PASLTP sessions can augment LTP-like plasticity in human M1. Findings may inspire further research on optimized therapeutic applications of non-invasive brain stimulation in neurological and psychiatric diseases.http://europepmc.org/articles/PMC4482149?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Florian Müller-Dahlhaus Caroline Lücke Ming-Kuei Lu Noritoshi Arai Anna Fuhl Eva Herrmann Ulf Ziemann |
spellingShingle |
Florian Müller-Dahlhaus Caroline Lücke Ming-Kuei Lu Noritoshi Arai Anna Fuhl Eva Herrmann Ulf Ziemann Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation. PLoS ONE |
author_facet |
Florian Müller-Dahlhaus Caroline Lücke Ming-Kuei Lu Noritoshi Arai Anna Fuhl Eva Herrmann Ulf Ziemann |
author_sort |
Florian Müller-Dahlhaus |
title |
Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation. |
title_short |
Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation. |
title_full |
Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation. |
title_fullStr |
Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation. |
title_full_unstemmed |
Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation. |
title_sort |
augmenting ltp-like plasticity in human motor cortex by spaced paired associative stimulation. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Paired associative stimulation (PASLTP) of the human primary motor cortex (M1) can induce LTP-like plasticity by increasing corticospinal excitability beyond the stimulation period. Previous studies showed that two consecutive PASLTP protocols interact by homeostatic metaplasticity, but animal experiments provided evidence that LTP can be augmented by repeated stimulation protocols spaced by ~30 min. Here we tested in twelve healthy selected PASLTP responders the possibility that LTP-like plasticity can be augmented in the human M1 by systematically varying the interval between two consecutive PASLTP protocols. The first PASLTP protocol (PAS1) induced strong LTP-like plasticity lasting for 30-60 min. The effect of a second identical PASLTP protocol (PAS2) critically depended on the time between PAS1 and PAS2. At 10 min, PAS2 prolonged the PAS1-induced LTP-like plasticity. At 30 min, PAS2 augmented the LTP-like plasticity induced by PAS1, by increasing both magnitude and duration. At 60 min and 180 min, PAS2 had no effect on corticospinal excitability. The cumulative LTP-like plasticity after PAS1 and PAS2 at 30 min exceeded significantly the effect of PAS1 alone, and the cumulative PAS1 and PAS2 effects at 60 min and 180 min. In summary, consecutive PASLTP protocols interact in human M1 in a time-dependent manner. If spaced by 30 min, two consecutive PASLTP sessions can augment LTP-like plasticity in human M1. Findings may inspire further research on optimized therapeutic applications of non-invasive brain stimulation in neurological and psychiatric diseases. |
url |
http://europepmc.org/articles/PMC4482149?pdf=render |
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