Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans
Prostate cancer (PC) is the second leading cause of cancer death in men. Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking. Veteran American men (272 controls and 144 PC cases) who attended the Durham...
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doaj-f11aab6fddc847ce8bb5b252eacfa4b02020-11-25T00:03:24ZengHindawi LimitedJournal of Cancer Epidemiology1687-85581687-85662012-01-01201210.1155/2012/957467957467Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American VeteransAdriana C. Vidal0Delores J. Grant1Christina D. Williams2Elizabeth Masko3Emma H. Allott4Kathryn Shuler5Megan McPhail6Alexis Gaines7Elizabeth Calloway8Leah Gerber9Jen-Tsan Chi10Stephen J. Freedland11Cathrine Hoyo12Department of Obstetrics and Gynecology and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC 27710, USADepartment of Biology and Cancer Research Program, JLC-Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USACenter for Health Services Research in Primary Care and Department of Hematology/Oncology, Durham VA Medical Center, Durham, NC 27705, USADivision of Urology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USADepartment of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC 27710, USADivision of Urology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USADuke Prostate Center, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USADuke Prostate Center, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USADivision of Urology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USADuke Prostate Center, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USAInstitute for Genome Sciences & Policy and Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27708, USADepartment of Surgery, Durham VA Medical Center, Durham, NC 27705, USADepartment of Obstetrics and Gynecology and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC 27710, USAProstate cancer (PC) is the second leading cause of cancer death in men. Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking. Veteran American men (272 controls and 144 PC cases) who attended the Durham Veteran American Medical Center between 2004–2009 were enrolled into a case-control study. Intake of folate, vitamin B12, B6, and methionine were measured using a food frequency questionnaire. Regression models were used to evaluate the association among one-carbon cycle nutrients, MTHFR genetic variants, and prostate cancer. Higher dietary methionine intake was associated with PC risk (OR = 2.1; 95%CI 1.1–3.9) The risk was most pronounced in men with Gleason sum <7 (OR = 2.75; 95%CI 1.32– 5.73). The association of higher methionine intake and PC risk was only apparent in men who carried at least one MTHFR A1298C allele (OR =6.7; 95%CI = 1.6–27.8), compared to MTHFR A1298A noncarrier men (OR =0.9; 95%CI = 0.24–3.92) (p-interaction =0.045). There was no evidence for associations between B vitamins (folate, B12, and B6) and PC risk. Our results suggest that carrying the MTHFR A1298C variants modifies the association between high methionine intake and PC risk. Larger studies are required to validate these findings.http://dx.doi.org/10.1155/2012/957467 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adriana C. Vidal Delores J. Grant Christina D. Williams Elizabeth Masko Emma H. Allott Kathryn Shuler Megan McPhail Alexis Gaines Elizabeth Calloway Leah Gerber Jen-Tsan Chi Stephen J. Freedland Cathrine Hoyo |
spellingShingle |
Adriana C. Vidal Delores J. Grant Christina D. Williams Elizabeth Masko Emma H. Allott Kathryn Shuler Megan McPhail Alexis Gaines Elizabeth Calloway Leah Gerber Jen-Tsan Chi Stephen J. Freedland Cathrine Hoyo Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans Journal of Cancer Epidemiology |
author_facet |
Adriana C. Vidal Delores J. Grant Christina D. Williams Elizabeth Masko Emma H. Allott Kathryn Shuler Megan McPhail Alexis Gaines Elizabeth Calloway Leah Gerber Jen-Tsan Chi Stephen J. Freedland Cathrine Hoyo |
author_sort |
Adriana C. Vidal |
title |
Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans |
title_short |
Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans |
title_full |
Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans |
title_fullStr |
Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans |
title_full_unstemmed |
Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans |
title_sort |
associations between intake of folate, methionine, and vitamins b-12, b-6 and prostate cancer risk in american veterans |
publisher |
Hindawi Limited |
series |
Journal of Cancer Epidemiology |
issn |
1687-8558 1687-8566 |
publishDate |
2012-01-01 |
description |
Prostate cancer (PC) is the second leading cause of cancer death in men. Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking. Veteran American men (272 controls and 144 PC cases) who attended the Durham Veteran American Medical Center between 2004–2009 were enrolled into a case-control study. Intake of folate, vitamin B12, B6, and methionine were measured using a food frequency questionnaire. Regression models were used to evaluate the association among one-carbon cycle nutrients, MTHFR genetic variants, and prostate cancer. Higher dietary methionine intake was associated with PC risk (OR = 2.1; 95%CI 1.1–3.9) The risk was most pronounced in men with Gleason sum <7 (OR = 2.75; 95%CI 1.32– 5.73). The association of higher methionine intake and PC risk was only apparent in men who carried at least one MTHFR A1298C allele (OR =6.7; 95%CI = 1.6–27.8), compared to MTHFR A1298A noncarrier men (OR =0.9; 95%CI = 0.24–3.92) (p-interaction =0.045). There was no evidence for associations between B vitamins (folate, B12, and B6) and PC risk. Our results suggest that carrying the MTHFR A1298C variants modifies the association between high methionine intake and PC risk. Larger studies are required to validate these findings. |
url |
http://dx.doi.org/10.1155/2012/957467 |
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