Acoustic Angiography: A New Imaging Modality for Assessing Microvasculature Architecture
The purpose of this paper is to provide the biomedical imaging community with details of a new high resolution contrast imaging approach referred to as “acoustic angiography.” Through the use of dual-frequency ultrasound transducer technology, images acquired with this approach possess both high res...
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Online Access: | http://dx.doi.org/10.1155/2013/936593 |
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doaj-f11c8e80f4d84151a7754a9f1c5ce9812020-11-24T21:13:35ZengHindawi LimitedInternational Journal of Biomedical Imaging1687-41881687-41962013-01-01201310.1155/2013/936593936593Acoustic Angiography: A New Imaging Modality for Assessing Microvasculature ArchitectureRyan C. Gessner0C. Brandon Frederick1F. Stuart Foster2Paul A. Dayton3UNC and NCSU Joint Department of Biomedical Engineering, 304 Taylor Hall, 109 Mason Farm Road, Chapel Hill, NC 27599-6136, USAUNC and NCSU Joint Department of Biomedical Engineering, 304 Taylor Hall, 109 Mason Farm Road, Chapel Hill, NC 27599-6136, USADepartment of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, CanadaUNC and NCSU Joint Department of Biomedical Engineering, 304 Taylor Hall, 109 Mason Farm Road, Chapel Hill, NC 27599-6136, USAThe purpose of this paper is to provide the biomedical imaging community with details of a new high resolution contrast imaging approach referred to as “acoustic angiography.” Through the use of dual-frequency ultrasound transducer technology, images acquired with this approach possess both high resolution and a high contrast-to-tissue ratio, which enables the visualization of microvascular architecture without significant contribution from background tissues. Additionally, volumetric vessel-tissue integration can be visualized by using b-mode overlays acquired with the same probe. We present a brief technical overview of how the images are acquired, followed by several examples of images of both healthy and diseased tissue volumes. 3D images from alternate modalities often used in preclinical imaging, contrast-enhanced micro-CT and photoacoustics, are also included to provide a perspective on how acoustic angiography has qualitatively similar capabilities to these other techniques. These preliminary images provide visually compelling evidence to suggest that acoustic angiography may serve as a powerful new tool in preclinical and future clinical imaging.http://dx.doi.org/10.1155/2013/936593 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ryan C. Gessner C. Brandon Frederick F. Stuart Foster Paul A. Dayton |
spellingShingle |
Ryan C. Gessner C. Brandon Frederick F. Stuart Foster Paul A. Dayton Acoustic Angiography: A New Imaging Modality for Assessing Microvasculature Architecture International Journal of Biomedical Imaging |
author_facet |
Ryan C. Gessner C. Brandon Frederick F. Stuart Foster Paul A. Dayton |
author_sort |
Ryan C. Gessner |
title |
Acoustic Angiography: A New Imaging Modality for Assessing Microvasculature Architecture |
title_short |
Acoustic Angiography: A New Imaging Modality for Assessing Microvasculature Architecture |
title_full |
Acoustic Angiography: A New Imaging Modality for Assessing Microvasculature Architecture |
title_fullStr |
Acoustic Angiography: A New Imaging Modality for Assessing Microvasculature Architecture |
title_full_unstemmed |
Acoustic Angiography: A New Imaging Modality for Assessing Microvasculature Architecture |
title_sort |
acoustic angiography: a new imaging modality for assessing microvasculature architecture |
publisher |
Hindawi Limited |
series |
International Journal of Biomedical Imaging |
issn |
1687-4188 1687-4196 |
publishDate |
2013-01-01 |
description |
The purpose of this paper is to provide the biomedical imaging community with details of a new high resolution contrast imaging approach referred to as “acoustic angiography.” Through the use of dual-frequency ultrasound transducer technology, images acquired with this approach possess both high resolution and a high contrast-to-tissue ratio, which enables the visualization of microvascular architecture without significant contribution from background tissues. Additionally, volumetric vessel-tissue integration can be visualized by using b-mode overlays acquired with the same probe. We present a brief technical overview of how the images are acquired, followed by several examples of images of both healthy and diseased tissue volumes. 3D images from alternate modalities often used in preclinical imaging, contrast-enhanced micro-CT and photoacoustics, are also included to provide a perspective on how acoustic angiography has qualitatively similar capabilities to these other techniques. These preliminary images provide visually compelling evidence to suggest that acoustic angiography may serve as a powerful new tool in preclinical and future clinical imaging. |
url |
http://dx.doi.org/10.1155/2013/936593 |
work_keys_str_mv |
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