Preferential amplification of repetitive DNA during whole genome sequencing library creation from historic samples

Preferential amplification of repetitive DNA during whole genome sequencing library creation from historic samples

Repetitive microsatellite DNA forms a universal component of eukaryote genomes and specific biochemical properties of such repeat regions may influence the outcome of laboratory protocols. The Atlantic cod (Gadus morhua) genome contains an order of magnitude more dinucleotide repeats than the majori...

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Bibliographic Details
Main Authors: Bastiaan Star, Marianne HS Hansen, Morten Skage, Ian R. Bradbury, Jane A. Godiksen, Olav S. Kjesbu, Sissel Jentoft
Format: Article
Language:English
Published: Taylor & Francis Group 2016-01-01
Series:Science and Technology of Archaeological Research
Subjects:
dinucleotide repeats
self-priming
repetitive DNA
amplification bias
aDNA
Atlantic cod
Online Access:http://dx.doi.org/10.1080/20548923.2016.1160594

Internet

http://dx.doi.org/10.1080/20548923.2016.1160594

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