Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines

Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines

Chiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.

Bibliographic Details
Main Authors: Dan Liu, Bowen Li, Jianzhong Chen, Ilya D. Gridnev, Deyue Yan, Wanbin Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19807-5
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spelling doaj-f1244b61e228435dbc80c849602094712021-01-31T13:19:40ZengNature Publishing GroupNature Communications2041-17232020-11-011111910.1038/s41467-020-19807-5Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycinesDan Liu0Bowen Li1Jianzhong Chen2Ilya D. Gridnev3Deyue Yan4Wanbin Zhang5Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversityShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversityShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversityDepartment of Chemistry, Graduate School of Science, Tohoku UniversityShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversityShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversityChiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.https://doi.org/10.1038/s41467-020-19807-5
collection DOAJ
language English
format Article
sources DOAJ
author Dan Liu
Bowen Li
Jianzhong Chen
Ilya D. Gridnev
Deyue Yan
Wanbin Zhang
spellingShingle Dan Liu
Bowen Li
Jianzhong Chen
Ilya D. Gridnev
Deyue Yan
Wanbin Zhang
Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
Nature Communications
author_facet Dan Liu
Bowen Li
Jianzhong Chen
Ilya D. Gridnev
Deyue Yan
Wanbin Zhang
author_sort Dan Liu
title Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_short Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_full Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_fullStr Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_full_unstemmed Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
title_sort ni-catalyzed asymmetric hydrogenation of n-aryl imino esters for the efficient synthesis of chiral α-aryl glycines
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Chiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.
url https://doi.org/10.1038/s41467-020-19807-5
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AT jianzhongchen nicatalyzedasymmetrichydrogenationofnaryliminoestersfortheefficientsynthesisofchiralaarylglycines
AT ilyadgridnev nicatalyzedasymmetrichydrogenationofnaryliminoestersfortheefficientsynthesisofchiralaarylglycines
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