A Review of Nephrotoxicity of Microcystins
Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies h...
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MDPI AG
2020-10-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/12/11/693 |
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doaj-f1396437ba964accbb71091506ef46db2020-11-25T03:33:55ZengMDPI AGToxins2072-66512020-10-011269369310.3390/toxins12110693A Review of Nephrotoxicity of MicrocystinsShuaishuai Xu0Xiping Yi1Wenya Liu2Chengcheng Zhang3Isaac Yaw Massey4Fei Yang5Li Tian6Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan, ChinaSchool of Public Health, Xiangnan University, Chenzhou 423000, ChinaHunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan, ChinaHunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan, ChinaHunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan, ChinaHunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang 421001, ChinaDepartment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, ChinaCyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies have suggested that aside liver, the kidney may be another target organ of MCs intoxication. Therefore, this review provides various evidences on the nephrotoxicity of MCs. The review concludes that nephrotoxicity of MCs may be related to inhibition of protein phosphatases and excessive production of reactive oxygen species, cytoskeleton disruption, endoplasmic reticulum stress, DNA damage and cell apoptosis. To protect human from MCs toxic consequences, this paper also puts forward some directions for further research.https://www.mdpi.com/2072-6651/12/11/693microcystinsnephrotoxicityphosphatases 2Aoxidative stressapoptosis |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shuaishuai Xu Xiping Yi Wenya Liu Chengcheng Zhang Isaac Yaw Massey Fei Yang Li Tian |
| spellingShingle |
Shuaishuai Xu Xiping Yi Wenya Liu Chengcheng Zhang Isaac Yaw Massey Fei Yang Li Tian A Review of Nephrotoxicity of Microcystins Toxins microcystins nephrotoxicity phosphatases 2A oxidative stress apoptosis |
| author_facet |
Shuaishuai Xu Xiping Yi Wenya Liu Chengcheng Zhang Isaac Yaw Massey Fei Yang Li Tian |
| author_sort |
Shuaishuai Xu |
| title |
A Review of Nephrotoxicity of Microcystins |
| title_short |
A Review of Nephrotoxicity of Microcystins |
| title_full |
A Review of Nephrotoxicity of Microcystins |
| title_fullStr |
A Review of Nephrotoxicity of Microcystins |
| title_full_unstemmed |
A Review of Nephrotoxicity of Microcystins |
| title_sort |
review of nephrotoxicity of microcystins |
| publisher |
MDPI AG |
| series |
Toxins |
| issn |
2072-6651 |
| publishDate |
2020-10-01 |
| description |
Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies have suggested that aside liver, the kidney may be another target organ of MCs intoxication. Therefore, this review provides various evidences on the nephrotoxicity of MCs. The review concludes that nephrotoxicity of MCs may be related to inhibition of protein phosphatases and excessive production of reactive oxygen species, cytoskeleton disruption, endoplasmic reticulum stress, DNA damage and cell apoptosis. To protect human from MCs toxic consequences, this paper also puts forward some directions for further research. |
| topic |
microcystins nephrotoxicity phosphatases 2A oxidative stress apoptosis |
| url |
https://www.mdpi.com/2072-6651/12/11/693 |
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