Role of Nanomedicine in Redox Mediated Healing at Molecular Level
Nanomedicine, the offspring born from the marriage of nanotechnology and medicine, has already brought momentous advances in the fight against a plethora of unmet diseases from cardiovascular and neurodegenerative to diabetes and cancer. Here, we review a conceptual framework that will provide a bas...
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doaj-f143ed2fab5d44029f909db1d34590792021-09-05T20:42:36ZengDe GruyterBiomolecular Concepts1868-50211868-503X2019-10-0110116017410.1515/bmc-2019-0019bmc-2019-0019Role of Nanomedicine in Redox Mediated Healing at Molecular LevelAdhikari Aniruddha0Mondal Susmita1Darbar Soumendra2Kumar Pal Samir3Department of Chemical Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata-700106, IndiaDepartment of Chemical Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata-700106, IndiaResearch & Development Division, Dey’s Medical Stores (Mfg.) Ltd, 62, Bondel Road, Ballygunge, Kolkata 700019, IndiaDepartment of Chemical Biological and Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector 3, Salt Lake, Kolkata-700106, IndiaNanomedicine, the offspring born from the marriage of nanotechnology and medicine, has already brought momentous advances in the fight against a plethora of unmet diseases from cardiovascular and neurodegenerative to diabetes and cancer. Here, we review a conceptual framework that will provide a basic understanding about the molecular mechanism of action of a therapeutic nanomaterial inside biological milieu. In this review, we highlight how the catalytic nature of a transition metal oxide nanomaterial influences the cellular redox homeostasis, supports the cellular antioxidant defence system and reactivates the reactive oxygen species (ROS) mediated signalling to perform normal cell functions like cell cycle, differentiation, apoptosis, inflammation, toxicity, and protein interactions. With numerous examples, we describe the redox modulatory nature of d-block metal oxide nanomaterials and their biomimetic nanozyme activities to protect the mitochondria, the cellular redox mediator which prevents an organism from various diseases. This knowledge will be useful to design new nanomaterials capable of intracellular redox modulation, which in turn can be effective therapeutic agents for treatment of various unmet diseases that are beyond the ability of modern synthetic medicine.https://doi.org/10.1515/bmc-2019-0019nanotherapycellular redox homeostasisnanozymereactive oxygen speciessurface functionalization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adhikari Aniruddha Mondal Susmita Darbar Soumendra Kumar Pal Samir |
spellingShingle |
Adhikari Aniruddha Mondal Susmita Darbar Soumendra Kumar Pal Samir Role of Nanomedicine in Redox Mediated Healing at Molecular Level Biomolecular Concepts nanotherapy cellular redox homeostasis nanozyme reactive oxygen species surface functionalization |
author_facet |
Adhikari Aniruddha Mondal Susmita Darbar Soumendra Kumar Pal Samir |
author_sort |
Adhikari Aniruddha |
title |
Role of Nanomedicine in Redox Mediated Healing at Molecular Level |
title_short |
Role of Nanomedicine in Redox Mediated Healing at Molecular Level |
title_full |
Role of Nanomedicine in Redox Mediated Healing at Molecular Level |
title_fullStr |
Role of Nanomedicine in Redox Mediated Healing at Molecular Level |
title_full_unstemmed |
Role of Nanomedicine in Redox Mediated Healing at Molecular Level |
title_sort |
role of nanomedicine in redox mediated healing at molecular level |
publisher |
De Gruyter |
series |
Biomolecular Concepts |
issn |
1868-5021 1868-503X |
publishDate |
2019-10-01 |
description |
Nanomedicine, the offspring born from the marriage of nanotechnology and medicine, has already brought momentous advances in the fight against a plethora of unmet diseases from cardiovascular and neurodegenerative to diabetes and cancer. Here, we review a conceptual framework that will provide a basic understanding about the molecular mechanism of action of a therapeutic nanomaterial inside biological milieu. In this review, we highlight how the catalytic nature of a transition metal oxide nanomaterial influences the cellular redox homeostasis, supports the cellular antioxidant defence system and reactivates the reactive oxygen species (ROS) mediated signalling to perform normal cell functions like cell cycle, differentiation, apoptosis, inflammation, toxicity, and protein interactions. With numerous examples, we describe the redox modulatory nature of d-block metal oxide nanomaterials and their biomimetic nanozyme activities to protect the mitochondria, the cellular redox mediator which prevents an organism from various diseases. This knowledge will be useful to design new nanomaterials capable of intracellular redox modulation, which in turn can be effective therapeutic agents for treatment of various unmet diseases that are beyond the ability of modern synthetic medicine. |
topic |
nanotherapy cellular redox homeostasis nanozyme reactive oxygen species surface functionalization |
url |
https://doi.org/10.1515/bmc-2019-0019 |
work_keys_str_mv |
AT adhikarianiruddha roleofnanomedicineinredoxmediatedhealingatmolecularlevel AT mondalsusmita roleofnanomedicineinredoxmediatedhealingatmolecularlevel AT darbarsoumendra roleofnanomedicineinredoxmediatedhealingatmolecularlevel AT kumarpalsamir roleofnanomedicineinredoxmediatedhealingatmolecularlevel |
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1717785451290427392 |