β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes
Thioredoxin 1 (Trx1) is a major antioxidant that acts adaptively to protect the heart during the development of diabetic cardiomyopathy. The molecular mechanism(s) responsible for regulating the Trx1 level and/or activity during diabetic cardiomyopathy is unknown. β-hydroxybutyrate (βHB), a major ke...
Main Authors: | Shin-ichi Oka, Fan Tang, Adave Chin, Guersom Ralda, Xiaoyong Xu, Chengchen Hu, Zhi Yang, Maha Abdellatif, Junichi Sadoshima |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
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Series: | Antioxidants |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3921/10/7/1153 |
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