Effect of quercetin on learning and memory in STZ-induced diabetic rat
Background and Objective: Diabetes mellitus is common endocrine disease cause learning and memory impairment. This study was done to evaluate the effect of quercetin on learning and memory in STZ-induced diabetic rats was investigated. Methods: In this experimental study, 40 male Wistar rats were ra...
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Golestan University of Medical Sciences
2014-10-01
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doaj-f1440ab1def34c08bc53d6cb4e122ed72020-11-24T21:50:09ZfasGolestan University of Medical Sciences مجله دانشگاه علوم پزشکی گرگان1562-47652008-40802014-10-011643441Effect of quercetin on learning and memory in STZ-induced diabetic ratNasri S0Rahimi M1Mozafari M2 Associate Professor, Department of Biology, Payamenoor University, Tehran, Iran M.Sc in Biology, Department of Biology, Payamenoor University, Tehran, Iran M.Sc in Biology, Department of Biology, Payamenoor University, Tehran, Iran Background and Objective: Diabetes mellitus is common endocrine disease cause learning and memory impairment. This study was done to evaluate the effect of quercetin on learning and memory in STZ-induced diabetic rats was investigated. Methods: In this experimental study, 40 male Wistar rats were randomly allocated into five groups: control, quercetin - treated control, diabetic and quercetin - treated diabetic (10 and 20 mg/kg/bw, intraperitoneally) for 14 days. Induction of diabetes was performed using 60 mg/kg/bw of streptozotosin, interapritonally. Passive avoidance and Y-maze tests were used for the evaluation of learning and memory. Results: In passive avoidance learning, there was no significant difference in initial latency between diabetic and treated - diabetic groups. The mean of step latency in control group (383.57±19.26) significantly reduced to 128.86±10.38 in diabetic group (P<0.05). The mean of step latency in the treated diabetic group significantly increased in compare to the diabetic group (P<0.05). Step latency in quercetin - treated diabetic (10 mg/kg/bw) and (20 mg/kg/bw) groups increased to 316.67±23.76 and 397.50±31.21, respectively. The alternative percentage in diabetic group was significantly lower than control group (P<0.05), but in quercetin -treated diabetic groups it was higher than the diabetic group (P<0.05). Conclusion: Administration of quercetin for 14 days enhances the capability of the memory storage, recall and improves short-term spatial memory in STZ-induced diabetic rats.http://goums.ac.ir/journal/browse.php?a_code=A-10-1-783&slc_lang=en&sid=1DiabetesQuercetinLearningMemoryRat |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Nasri S Rahimi M Mozafari M |
spellingShingle |
Nasri S Rahimi M Mozafari M Effect of quercetin on learning and memory in STZ-induced diabetic rat مجله دانشگاه علوم پزشکی گرگان Diabetes Quercetin Learning Memory Rat |
author_facet |
Nasri S Rahimi M Mozafari M |
author_sort |
Nasri S |
title |
Effect of quercetin on learning and memory in STZ-induced diabetic rat |
title_short |
Effect of quercetin on learning and memory in STZ-induced diabetic rat |
title_full |
Effect of quercetin on learning and memory in STZ-induced diabetic rat |
title_fullStr |
Effect of quercetin on learning and memory in STZ-induced diabetic rat |
title_full_unstemmed |
Effect of quercetin on learning and memory in STZ-induced diabetic rat |
title_sort |
effect of quercetin on learning and memory in stz-induced diabetic rat |
publisher |
Golestan University of Medical Sciences |
series |
مجله دانشگاه علوم پزشکی گرگان |
issn |
1562-4765 2008-4080 |
publishDate |
2014-10-01 |
description |
Background and Objective: Diabetes mellitus is common endocrine disease cause learning and memory impairment. This study was done to evaluate the effect of quercetin on learning and memory in STZ-induced diabetic rats was investigated. Methods: In this experimental study, 40 male Wistar rats were randomly allocated into five groups: control, quercetin - treated control, diabetic and quercetin - treated diabetic (10 and 20 mg/kg/bw, intraperitoneally) for 14 days. Induction of diabetes was performed using 60 mg/kg/bw of streptozotosin, interapritonally. Passive avoidance and Y-maze tests were used for the evaluation of learning and memory. Results: In passive avoidance learning, there was no significant difference in initial latency between diabetic and treated - diabetic groups. The mean of step latency in control group (383.57±19.26) significantly reduced to 128.86±10.38 in diabetic group (P<0.05). The mean of step latency in the treated diabetic group significantly increased in compare to the diabetic group (P<0.05). Step latency in quercetin - treated diabetic (10 mg/kg/bw) and (20 mg/kg/bw) groups increased to 316.67±23.76 and 397.50±31.21, respectively. The alternative percentage in diabetic group was significantly lower than control group (P<0.05), but in quercetin -treated diabetic groups it was higher than the diabetic group (P<0.05). Conclusion: Administration of quercetin for 14 days enhances the capability of the memory storage, recall and improves short-term spatial memory in STZ-induced diabetic rats. |
topic |
Diabetes Quercetin Learning Memory Rat |
url |
http://goums.ac.ir/journal/browse.php?a_code=A-10-1-783&slc_lang=en&sid=1 |
work_keys_str_mv |
AT nasris effectofquercetinonlearningandmemoryinstzinduceddiabeticrat AT rahimim effectofquercetinonlearningandmemoryinstzinduceddiabeticrat AT mozafarim effectofquercetinonlearningandmemoryinstzinduceddiabeticrat |
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