ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells
Melanoma cells have been shown to undergo fast amoeboid (leader bleb-based) migration, requiring a single large bleb for migration. In leader blebs, is a rapid flow of cortical actin that drives the cell forward. Using RNAi, we find that co-depleting cofilin-1 and actin depolymerizing factor (ADF) l...
Main Authors: | Maria F Ullo, Jeremy S Logue |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-06-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/67856 |
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