Defining the Role of Oxygen Tension in Human Neural Progenitor Fate

Defining the Role of Oxygen Tension in Human Neural Progenitor Fate

Hypoxia augments human embryonic stem cell (hESC) self-renewal via hypoxia-inducible factor 2α-activated OCT4 transcription. Hypoxia also increases the efficiency of reprogramming differentiated cells to a pluripotent-like state. Combined, these findings suggest that low O2 tension would impair the...

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Bibliographic Details
Main Authors: Yuan Xie, Jin Zhang, Ying Lin, Xavier Gaeta, Xiangzhi Meng, Dona R.R. Wisidagama, Jessica Cinkornpumin, Carla M. Koehler, Cindy S. Malone, Michael A. Teitell, William E. Lowry
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114003063

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http://www.sciencedirect.com/science/article/pii/S2213671114003063

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