The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in rats
Objective: Achillea millefolium (A. millefolium) is known as an orexigenic herb in Iranian traditional medicine. In this study, the possible orexigenic effect of hydro-alcoholic extract of A. millefolium was investigated by measuring plasma ghrelin level.Materials and Methods: Thirty male Wistar rat...
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doaj-f15359a6b107422490a6f96455949b562020-11-24T20:59:39ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492017-01-0171101510.22038/ajp.2016.64926492The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in ratsMohsen Nematy0Mohsen Mazidi1Atefeh Jafari2Sara Baghban3Hasan Rakhshandeh4Abdolreza Norouzy5Habibollah Esmaily6Leila Etemad7Michael Patterson8Amir Houshang Mohammadpour9Biochemistry and Nutrition Research Center and Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, IranBiochemistry and Nutrition Research Center and Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranBiochemistry and Nutrition Research Center and Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, IranPharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranBiochemistry and Nutrition Research Center and Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, IranHealth Sciences Research Center, Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran6epartment of Life Sciences, University of Roehampton, London SW15 4JDPharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, IranObjective: Achillea millefolium (A. millefolium) is known as an orexigenic herb in Iranian traditional medicine. In this study, the possible orexigenic effect of hydro-alcoholic extract of A. millefolium was investigated by measuring plasma ghrelin level.Materials and Methods: Thirty male Wistar rats were divided into five groups. Control group received water. Treatment groups received 50, 100 or 150 mg/kg of A. millefolium extract for 7 days via gavage. Before the intervention, daily amount of the food eaten by each rat was measured for 10 days. During the investigation, the amount of energy intake of each rat was also estimated 1, 2, 4, 6 and 24 hr after each intake, for 7 days. Later, the orexigenic dose of extract and distilled water was fed to two separate groups of 6 male Wistar rats. Plasma ghrelin level was measured 0.5, 1, 2 and 4 hr after extract intake.Results: The change in energy intake after treatment by 50 and 100 mg/kg of the extract was significantly higher than other groups (phttp://ajp.mums.ac.ir/article_6492_146abbd35bdb8d9aed75fdebe87ce128.pdfAchillea MillefoliuAppetiteFood intakeGhrelinHydroalcoholic extract |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohsen Nematy Mohsen Mazidi Atefeh Jafari Sara Baghban Hasan Rakhshandeh Abdolreza Norouzy Habibollah Esmaily Leila Etemad Michael Patterson Amir Houshang Mohammadpour |
spellingShingle |
Mohsen Nematy Mohsen Mazidi Atefeh Jafari Sara Baghban Hasan Rakhshandeh Abdolreza Norouzy Habibollah Esmaily Leila Etemad Michael Patterson Amir Houshang Mohammadpour The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in rats Avicenna Journal of Phytomedicine Achillea Millefoliu Appetite Food intake Ghrelin Hydroalcoholic extract |
author_facet |
Mohsen Nematy Mohsen Mazidi Atefeh Jafari Sara Baghban Hasan Rakhshandeh Abdolreza Norouzy Habibollah Esmaily Leila Etemad Michael Patterson Amir Houshang Mohammadpour |
author_sort |
Mohsen Nematy |
title |
The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in rats |
title_short |
The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in rats |
title_full |
The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in rats |
title_fullStr |
The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in rats |
title_full_unstemmed |
The effect of hydro-alcoholic extract of Achillea millefolium on appetite hormone in rats |
title_sort |
effect of hydro-alcoholic extract of achillea millefolium on appetite hormone in rats |
publisher |
Mashhad University of Medical Sciences |
series |
Avicenna Journal of Phytomedicine |
issn |
2228-7930 2228-7949 |
publishDate |
2017-01-01 |
description |
Objective: Achillea millefolium (A. millefolium) is known as an orexigenic herb in Iranian traditional medicine. In this study, the possible orexigenic effect of hydro-alcoholic extract of A. millefolium was investigated by measuring plasma ghrelin level.Materials and Methods: Thirty male Wistar rats were divided into five groups. Control group received water. Treatment groups received 50, 100 or 150 mg/kg of A. millefolium extract for 7 days via gavage. Before the intervention, daily amount of the food eaten by each rat was measured for 10 days. During the investigation, the amount of energy intake of each rat was also estimated 1, 2, 4, 6 and 24 hr after each intake, for 7 days. Later, the orexigenic dose of extract and distilled water was fed to two separate groups of 6 male Wistar rats. Plasma ghrelin level was measured 0.5, 1, 2 and 4 hr after extract intake.Results: The change in energy intake after treatment by 50 and 100 mg/kg of the extract was significantly higher than other groups (p |
topic |
Achillea Millefoliu Appetite Food intake Ghrelin Hydroalcoholic extract |
url |
http://ajp.mums.ac.ir/article_6492_146abbd35bdb8d9aed75fdebe87ce128.pdf |
work_keys_str_mv |
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