The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day
A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, t...
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2019-02-01
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| Series: | International Journal of Environmental Research and Public Health |
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| Online Access: | https://www.mdpi.com/1660-4601/16/4/553 |
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doaj-f1583f75893c47699d40769026a42b612020-11-25T02:00:08ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012019-02-0116455310.3390/ijerph16040553ijerph16040553The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/dayHongyan Zhu0Rui Li1Su Zhou2Suhui Zhang3Yu Wang4Shihong Liu5Qingwen Song6Xiuli Chang7Yubin Zhang8Luqing Liu9Liming Tang10Zhijun Zhou11Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, ChinaPharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, ChinaPharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, ChinaPharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, ChinaPharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, ChinaSchool of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, ChinaSchool of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, ChinaSchool of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, ChinaSchool of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, ChinaSchool of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, ChinaPharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, ChinaSchool of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, ChinaA ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide.https://www.mdpi.com/1660-4601/16/4/553Flurochloridonesubchronic toxicityNOAELmale reproductive system |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hongyan Zhu Rui Li Su Zhou Suhui Zhang Yu Wang Shihong Liu Qingwen Song Xiuli Chang Yubin Zhang Luqing Liu Liming Tang Zhijun Zhou |
| spellingShingle |
Hongyan Zhu Rui Li Su Zhou Suhui Zhang Yu Wang Shihong Liu Qingwen Song Xiuli Chang Yubin Zhang Luqing Liu Liming Tang Zhijun Zhou The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day International Journal of Environmental Research and Public Health Flurochloridone subchronic toxicity NOAEL male reproductive system |
| author_facet |
Hongyan Zhu Rui Li Su Zhou Suhui Zhang Yu Wang Shihong Liu Qingwen Song Xiuli Chang Yubin Zhang Luqing Liu Liming Tang Zhijun Zhou |
| author_sort |
Hongyan Zhu |
| title |
The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
| title_short |
The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
| title_full |
The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
| title_fullStr |
The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
| title_full_unstemmed |
The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
| title_sort |
oral noael of flurochloridone in male wistar rats in ninety-day subchronic toxicity test was 3mg/kg/day |
| publisher |
MDPI AG |
| series |
International Journal of Environmental Research and Public Health |
| issn |
1660-4601 |
| publishDate |
2019-02-01 |
| description |
A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide. |
| topic |
Flurochloridone subchronic toxicity NOAEL male reproductive system |
| url |
https://www.mdpi.com/1660-4601/16/4/553 |
| work_keys_str_mv |
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