A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which...

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Main Authors: Karem Shanab, Catharina Neudorfer, Wolfgang Holzer, Markus Mitterhauser, Wolfgang Wadsak, Helmut Spreitzer
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Molecules
Subjects:
chemoselective
alkylation
microwave
adenosine A3
PET
radiotracer
Online Access:http://www.mdpi.com/1420-3049/19/4/4076
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spelling doaj-f15a653bd7484c6595482b1df3f437da2020-11-25T01:57:20ZengMDPI AGMolecules1420-30492014-04-011944076408210.3390/molecules19044076molecules19044076A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET RadiotracerKarem Shanab0Catharina Neudorfer1Wolfgang Holzer2Markus Mitterhauser3Wolfgang Wadsak4Helmut Spreitzer5Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, AustriaThe synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2–8 in a single step.http://www.mdpi.com/1420-3049/19/4/4076chemoselectivealkylationmicrowaveadenosine A3PETradiotracer
collection DOAJ
language English
format Article
sources DOAJ
author Karem Shanab
Catharina Neudorfer
Wolfgang Holzer
Markus Mitterhauser
Wolfgang Wadsak
Helmut Spreitzer
spellingShingle Karem Shanab
Catharina Neudorfer
Wolfgang Holzer
Markus Mitterhauser
Wolfgang Wadsak
Helmut Spreitzer
A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
Molecules
chemoselective
alkylation
microwave
adenosine A3
PET
radiotracer
author_facet Karem Shanab
Catharina Neudorfer
Wolfgang Holzer
Markus Mitterhauser
Wolfgang Wadsak
Helmut Spreitzer
author_sort Karem Shanab
title A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_short A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_full A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_fullStr A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_full_unstemmed A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
title_sort one-step microwave-assisted synthetic method for an o/s-chemoselective route to derivatives of the first adenosine a3 pet radiotracer
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2014-04-01
description The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2–8 in a single step.
topic chemoselective
alkylation
microwave
adenosine A3
PET
radiotracer
url http://www.mdpi.com/1420-3049/19/4/4076
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