A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer
The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2014-04-01
|
Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/19/4/4076 |
id |
doaj-f15a653bd7484c6595482b1df3f437da |
---|---|
record_format |
Article |
spelling |
doaj-f15a653bd7484c6595482b1df3f437da2020-11-25T01:57:20ZengMDPI AGMolecules1420-30492014-04-011944076408210.3390/molecules19044076molecules19044076A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET RadiotracerKarem Shanab0Catharina Neudorfer1Wolfgang Holzer2Markus Mitterhauser3Wolfgang Wadsak4Helmut Spreitzer5Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDepartment of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, AustriaThe synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2–8 in a single step.http://www.mdpi.com/1420-3049/19/4/4076chemoselectivealkylationmicrowaveadenosine A3PETradiotracer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karem Shanab Catharina Neudorfer Wolfgang Holzer Markus Mitterhauser Wolfgang Wadsak Helmut Spreitzer |
spellingShingle |
Karem Shanab Catharina Neudorfer Wolfgang Holzer Markus Mitterhauser Wolfgang Wadsak Helmut Spreitzer A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer Molecules chemoselective alkylation microwave adenosine A3 PET radiotracer |
author_facet |
Karem Shanab Catharina Neudorfer Wolfgang Holzer Markus Mitterhauser Wolfgang Wadsak Helmut Spreitzer |
author_sort |
Karem Shanab |
title |
A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer |
title_short |
A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer |
title_full |
A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer |
title_fullStr |
A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer |
title_full_unstemmed |
A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer |
title_sort |
one-step microwave-assisted synthetic method for an o/s-chemoselective route to derivatives of the first adenosine a3 pet radiotracer |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2014-04-01 |
description |
The synthesis of reference standards and expected in vivo metabolites of the first adenosine A3 PET radiotracer [18F]FE@SUPPY ([18F]fluoroethyl 4,6-diethyl-5-[(ethyl-sulfanyl)carbonyl]-2-phenylpyridine-3-carboxylate) was achieved by using a straightforward microwave assisted alkylation method, which allowed O/S-chemoselective alkylation of the starting material 1 to give each target compound 2–8 in a single step. |
topic |
chemoselective alkylation microwave adenosine A3 PET radiotracer |
url |
http://www.mdpi.com/1420-3049/19/4/4076 |
work_keys_str_mv |
AT karemshanab aonestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT catharinaneudorfer aonestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT wolfgangholzer aonestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT markusmitterhauser aonestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT wolfgangwadsak aonestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT helmutspreitzer aonestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT karemshanab onestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT catharinaneudorfer onestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT wolfgangholzer onestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT markusmitterhauser onestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT wolfgangwadsak onestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer AT helmutspreitzer onestepmicrowaveassistedsyntheticmethodforanoschemoselectiveroutetoderivativesofthefirstadenosinea3petradiotracer |
_version_ |
1724974703572942848 |