Clinical features and outcomes of seven patients with COVID-19 in a family cluster
Abstract Background The family cluster is one of most important modes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission throughout China, and more details are needed about how family clusters cause the spread of coronavirus disease 2019 (COVID-19). Case presentation We ret...
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doaj-f15b596106c14d15a4af95619c830e9b2020-11-25T03:57:42ZengBMCBMC Infectious Diseases1471-23342020-09-0120111410.1186/s12879-020-05364-1Clinical features and outcomes of seven patients with COVID-19 in a family clusterYiling Zhang0Cheng Zhang1Ying Hu2Hongmei Yao3Xianchun Zeng4Changrong Hu5Li Zhao6Xiangyan Zhang7Xianwei Ye8Department of Respiratory and Critical Care Medicine, Guizhou Provincial People’s Hospital, State Key Laboratory of Diagnosis and Treatment of Lung Immune DiseasesDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People’s Hospital, State Key Laboratory of Diagnosis and Treatment of Lung Immune DiseasesDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People’s Hospital, State Key Laboratory of Diagnosis and Treatment of Lung Immune DiseasesDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People’s Hospital, State Key Laboratory of Diagnosis and Treatment of Lung Immune DiseasesDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People’s Hospital, State Key Laboratory of Diagnosis and Treatment of Lung Immune DiseasesDepartment of Respiratory Medicine, Panzhou People’s HospitalDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People’s Hospital, State Key Laboratory of Diagnosis and Treatment of Lung Immune DiseasesDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People’s Hospital, State Key Laboratory of Diagnosis and Treatment of Lung Immune DiseasesDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People’s Hospital, State Key Laboratory of Diagnosis and Treatment of Lung Immune DiseasesAbstract Background The family cluster is one of most important modes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission throughout China, and more details are needed about how family clusters cause the spread of coronavirus disease 2019 (COVID-19). Case presentation We retrospectively reviewed 7 confirmed cases from one family cluster. Both clinical features and laboratory examination results were described. Patient 1 had been in close contact with someone who was later confirmed to have COVID-19 in Wuhan City before he returned back to his hometown. He had dinner with 6 other members in his family. All the persons developed COVID-19 successively except for one older woman who neither had dinner with them nor shared a sleeping room with her husband. Six patients had mild or moderate COVID-19 but one older man with underlying diseases progressed into the severe type. After general and symptomatic treatments, all the patients recovered. Conclusions In a family cluster, having dinner together may be an important mode for the transmission of SARS-CoV-2. In this setting, most cases are mild with a favorable prognosis, while elderly patients with underlying diseases may progress into the severe type. For someone who has close contact with a confirmed case, 14-day isolation is necessary to contain virus transmission.http://link.springer.com/article/10.1186/s12879-020-05364-1Clinical featuresSARS-CoV-2COVID-19,family clusterCase report |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yiling Zhang Cheng Zhang Ying Hu Hongmei Yao Xianchun Zeng Changrong Hu Li Zhao Xiangyan Zhang Xianwei Ye |
spellingShingle |
Yiling Zhang Cheng Zhang Ying Hu Hongmei Yao Xianchun Zeng Changrong Hu Li Zhao Xiangyan Zhang Xianwei Ye Clinical features and outcomes of seven patients with COVID-19 in a family cluster BMC Infectious Diseases Clinical features SARS-CoV-2 COVID-19,family cluster Case report |
author_facet |
Yiling Zhang Cheng Zhang Ying Hu Hongmei Yao Xianchun Zeng Changrong Hu Li Zhao Xiangyan Zhang Xianwei Ye |
author_sort |
Yiling Zhang |
title |
Clinical features and outcomes of seven patients with COVID-19 in a family cluster |
title_short |
Clinical features and outcomes of seven patients with COVID-19 in a family cluster |
title_full |
Clinical features and outcomes of seven patients with COVID-19 in a family cluster |
title_fullStr |
Clinical features and outcomes of seven patients with COVID-19 in a family cluster |
title_full_unstemmed |
Clinical features and outcomes of seven patients with COVID-19 in a family cluster |
title_sort |
clinical features and outcomes of seven patients with covid-19 in a family cluster |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2020-09-01 |
description |
Abstract Background The family cluster is one of most important modes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission throughout China, and more details are needed about how family clusters cause the spread of coronavirus disease 2019 (COVID-19). Case presentation We retrospectively reviewed 7 confirmed cases from one family cluster. Both clinical features and laboratory examination results were described. Patient 1 had been in close contact with someone who was later confirmed to have COVID-19 in Wuhan City before he returned back to his hometown. He had dinner with 6 other members in his family. All the persons developed COVID-19 successively except for one older woman who neither had dinner with them nor shared a sleeping room with her husband. Six patients had mild or moderate COVID-19 but one older man with underlying diseases progressed into the severe type. After general and symptomatic treatments, all the patients recovered. Conclusions In a family cluster, having dinner together may be an important mode for the transmission of SARS-CoV-2. In this setting, most cases are mild with a favorable prognosis, while elderly patients with underlying diseases may progress into the severe type. For someone who has close contact with a confirmed case, 14-day isolation is necessary to contain virus transmission. |
topic |
Clinical features SARS-CoV-2 COVID-19,family cluster Case report |
url |
http://link.springer.com/article/10.1186/s12879-020-05364-1 |
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