DNA single-strand break-induced DNA damage response causes heart failure
DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes, which activate persistent DDR and trigger an NF-...
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Nature Publishing Group
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15104 |
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doaj-f167f426b5044f03bde4b9f896135c5c2021-05-11T07:02:26ZengNature Publishing GroupNature Communications2041-17232017-04-018111310.1038/ncomms15104DNA single-strand break-induced DNA damage response causes heart failureTomoaki Higo0Atsuhiko T. Naito1Tomokazu Sumida2Masato Shibamoto3Katsuki Okada4Seitaro Nomura5Akito Nakagawa6Toshihiro Yamaguchi7Taku Sakai8Akihito Hashimoto9Yuki Kuramoto10Masamichi Ito11Shungo Hikoso12Hiroshi Akazawa13Jong-Kook Lee14Ichiro Shiojima15Peter J. McKinnon16Yasushi Sakata17Issei Komuro18Department of Cardiovascular Medicine, Osaka University Graduate School of MedicineDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineCRESTDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineCRESTDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineDepartment of Cardiovascular Medicine, The University of Tokyo Graduate School of MedicineDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineDepartment of Cardiovascular Medicine, The University of Tokyo Graduate School of MedicineDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineCRESTDepartment of Genetics and Tumor Cell Biology, ST. Jude Children’s Research HospitalDepartment of Cardiovascular Medicine, Osaka University Graduate School of MedicineCRESTDNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes, which activate persistent DDR and trigger an NF-κB-dependent cardiac inflammation.https://doi.org/10.1038/ncomms15104 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Tomoaki Higo Atsuhiko T. Naito Tomokazu Sumida Masato Shibamoto Katsuki Okada Seitaro Nomura Akito Nakagawa Toshihiro Yamaguchi Taku Sakai Akihito Hashimoto Yuki Kuramoto Masamichi Ito Shungo Hikoso Hiroshi Akazawa Jong-Kook Lee Ichiro Shiojima Peter J. McKinnon Yasushi Sakata Issei Komuro |
| spellingShingle |
Tomoaki Higo Atsuhiko T. Naito Tomokazu Sumida Masato Shibamoto Katsuki Okada Seitaro Nomura Akito Nakagawa Toshihiro Yamaguchi Taku Sakai Akihito Hashimoto Yuki Kuramoto Masamichi Ito Shungo Hikoso Hiroshi Akazawa Jong-Kook Lee Ichiro Shiojima Peter J. McKinnon Yasushi Sakata Issei Komuro DNA single-strand break-induced DNA damage response causes heart failure Nature Communications |
| author_facet |
Tomoaki Higo Atsuhiko T. Naito Tomokazu Sumida Masato Shibamoto Katsuki Okada Seitaro Nomura Akito Nakagawa Toshihiro Yamaguchi Taku Sakai Akihito Hashimoto Yuki Kuramoto Masamichi Ito Shungo Hikoso Hiroshi Akazawa Jong-Kook Lee Ichiro Shiojima Peter J. McKinnon Yasushi Sakata Issei Komuro |
| author_sort |
Tomoaki Higo |
| title |
DNA single-strand break-induced DNA damage response causes heart failure |
| title_short |
DNA single-strand break-induced DNA damage response causes heart failure |
| title_full |
DNA single-strand break-induced DNA damage response causes heart failure |
| title_fullStr |
DNA single-strand break-induced DNA damage response causes heart failure |
| title_full_unstemmed |
DNA single-strand break-induced DNA damage response causes heart failure |
| title_sort |
dna single-strand break-induced dna damage response causes heart failure |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-04-01 |
| description |
DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes, which activate persistent DDR and trigger an NF-κB-dependent cardiac inflammation. |
| url |
https://doi.org/10.1038/ncomms15104 |
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