The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous Children
Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous chil...
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MDPI AG
2019-07-01
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| Series: | International Journal of Environmental Research and Public Health |
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| Online Access: | https://www.mdpi.com/1660-4601/16/15/2636 |
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doaj-f17155a2d02248f2916cb4f51481f89f2020-11-25T02:45:27ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012019-07-011615263610.3390/ijerph16152636ijerph16152636The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous ChildrenCarrington C. J. Shepherd0Holly D. Clifford1Francis Mitrou2Shannon M. Melody3Ellen J. Bennett4Fay H. Johnston5Luke D. Knibbs6Gavin Pereira7Janessa L. Pickering8Teck H. Teo9Lea-Ann S. Kirkham10Ruth B. Thornton11Anthony Kicic12Kak-Ming Ling13Zachary Alach14Matthew Lester15Peter Franklin16David Reid17Graeme R. Zosky18Telethon Kids Institute, University of Western Australia, Subiaco 6008, AustraliaTelethon Kids Institute, University of Western Australia, Subiaco 6008, AustraliaTelethon Kids Institute, University of Western Australia, Subiaco 6008, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart 7000, AustraliaSchool of Medicine, University of Tasmania, Hobart 7000, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart 7000, AustraliaSchool of Public Health, University of Queensland, Herston 4006, AustraliaSchool of Public Health, Curtin University, Bentley 6102, AustraliaTelethon Kids Institute, University of Western Australia, Subiaco 6008, AustraliaTelethon Kids Institute, University of Western Australia, Subiaco 6008, AustraliaTelethon Kids Institute, University of Western Australia, Subiaco 6008, AustraliaTelethon Kids Institute, University of Western Australia, Subiaco 6008, AustraliaTelethon Kids Institute, University of Western Australia, Subiaco 6008, AustraliaTelethon Kids Institute, University of Western Australia, Subiaco 6008, AustraliaEnvironmental Health Directorate, Western Australia Department of Health, Perth 6000, AustraliaEnvironmental Health Directorate, Western Australia Department of Health, Perth 6000, AustraliaSchool of Population and Global Health, The University of Western Australia, Crawley 6009, AustraliaQueensland Institute of Medical Research Berghofer, Brisbane 4000, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart 7000, AustraliaIndigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km<sup>2</sup>), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable <i>Haemophilus influenzae</i> (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02−3.06]) and lower (OR 1.99 95% CI [1.08−3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20−7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high.https://www.mdpi.com/1660-4601/16/15/2636Indigenouschild healthgeogenicparticulate matterbacterial infection |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Carrington C. J. Shepherd Holly D. Clifford Francis Mitrou Shannon M. Melody Ellen J. Bennett Fay H. Johnston Luke D. Knibbs Gavin Pereira Janessa L. Pickering Teck H. Teo Lea-Ann S. Kirkham Ruth B. Thornton Anthony Kicic Kak-Ming Ling Zachary Alach Matthew Lester Peter Franklin David Reid Graeme R. Zosky |
| spellingShingle |
Carrington C. J. Shepherd Holly D. Clifford Francis Mitrou Shannon M. Melody Ellen J. Bennett Fay H. Johnston Luke D. Knibbs Gavin Pereira Janessa L. Pickering Teck H. Teo Lea-Ann S. Kirkham Ruth B. Thornton Anthony Kicic Kak-Ming Ling Zachary Alach Matthew Lester Peter Franklin David Reid Graeme R. Zosky The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous Children International Journal of Environmental Research and Public Health Indigenous child health geogenic particulate matter bacterial infection |
| author_facet |
Carrington C. J. Shepherd Holly D. Clifford Francis Mitrou Shannon M. Melody Ellen J. Bennett Fay H. Johnston Luke D. Knibbs Gavin Pereira Janessa L. Pickering Teck H. Teo Lea-Ann S. Kirkham Ruth B. Thornton Anthony Kicic Kak-Ming Ling Zachary Alach Matthew Lester Peter Franklin David Reid Graeme R. Zosky |
| author_sort |
Carrington C. J. Shepherd |
| title |
The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous Children |
| title_short |
The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous Children |
| title_full |
The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous Children |
| title_fullStr |
The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous Children |
| title_full_unstemmed |
The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous Children |
| title_sort |
contribution of geogenic particulate matter to lung disease in indigenous children |
| publisher |
MDPI AG |
| series |
International Journal of Environmental Research and Public Health |
| issn |
1660-4601 |
| publishDate |
2019-07-01 |
| description |
Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km<sup>2</sup>), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable <i>Haemophilus influenzae</i> (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02−3.06]) and lower (OR 1.99 95% CI [1.08−3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20−7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high. |
| topic |
Indigenous child health geogenic particulate matter bacterial infection |
| url |
https://www.mdpi.com/1660-4601/16/15/2636 |
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