Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection

Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrop...

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Main Authors:	Ramya Sivangala Thandi, Rajesh Kumar Radhakrishnan, Deepak Tripathi, Padmaja Paidipally, Abul K. Azad, Larry S. Schlesinger, Buka Samten, Sachin Mulik, Ramakrishna Vankayalapati
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17310-5

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spelling	doaj-f17c1a1cefad4df6a818b7dcf60e439b2021-07-18T11:44:04ZengNature Publishing GroupNature Communications2041-17232020-07-0111111510.1038/s41467-020-17310-5Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infectionRamya Sivangala Thandi0Rajesh Kumar Radhakrishnan1Deepak Tripathi2Padmaja Paidipally3Abul K. Azad4Larry S. Schlesinger5Buka Samten6Sachin Mulik7Ramakrishna Vankayalapati8Department of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health CenterDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health CenterDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health CenterDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health CenterTexas Biomedical Research InstituteTexas Biomedical Research InstituteDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health CenterDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health CenterDepartment of Pulmonary Immunology, Center for Biomedical Research, University of Texas Health CenterKupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrophages when given intranasally to infected mice.https://doi.org/10.1038/s41467-020-17310-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ramya Sivangala Thandi Rajesh Kumar Radhakrishnan Deepak Tripathi Padmaja Paidipally Abul K. Azad Larry S. Schlesinger Buka Samten Sachin Mulik Ramakrishna Vankayalapati
spellingShingle	Ramya Sivangala Thandi Rajesh Kumar Radhakrishnan Deepak Tripathi Padmaja Paidipally Abul K. Azad Larry S. Schlesinger Buka Samten Sachin Mulik Ramakrishna Vankayalapati Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection Nature Communications
author_facet	Ramya Sivangala Thandi Rajesh Kumar Radhakrishnan Deepak Tripathi Padmaja Paidipally Abul K. Azad Larry S. Schlesinger Buka Samten Sachin Mulik Ramakrishna Vankayalapati
author_sort	Ramya Sivangala Thandi
title	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_short	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_full	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_fullStr	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_full_unstemmed	Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
title_sort	ornithine-a urea cycle metabolite enhances autophagy and controls mycobacterium tuberculosis infection
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Kupffer cells are more resistant to M. tuberculosis when compared with alveolar macrophages. Here the authors show that this distinction is caused by the presence of ornithine and imidazole in Kupffer cells and that these metabolites can drive autophagy and M. tuberculosis killing in alveolar macrophages when given intranasally to infected mice.
url	https://doi.org/10.1038/s41467-020-17310-5
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Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection

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