Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy

Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy

Abstract Background Neuroleukin (NLK) is a protein with neurotrophic properties and is present in a proportion of senile plaques and amyloid laden vessels. It has been suggested that NLK is part of a neuroprotective response to amyloid β-induced cell death. The aim of our study was to investigate th...

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Bibliographic Details
Main Authors: Anna M. De Kort, H. Bea Kuiperij, Daniel Alcolea, Iris Kersten, Alexandra A. M. Versleijen, Steven M. Greenberg, Erik Stoops, Floris H. B. M. Schreuder, Catharina J. M. Klijn, Alberto Lleó, Jurgen A. H. R. Claassen, Marcel M. Verbeek
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Alzheimer’s Research & Therapy
Subjects:
Cerebrospinal fluid
Biomarkers
Alzheimer’s disease
Amyloid
Cerebral amyloid angiopathy
Neuroleukin
Online Access:https://doi.org/10.1186/s13195-021-00899-0

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