Disentangling the complexity of tumor-derived extracellular vesicles

Disentangling the complexity of tumor-derived extracellular vesicles

Summary: The tumor microenvironment encompasses an intertwined ensemble of both transformed cancer cells and non-transformed host cells, which together establish a signaling network that regulates tumor progression. By conveying both homo- and heterotypic cell-to-cell communication cues, tumor-deriv...

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Main Authors: Tim Beltraminelli, Caleb R. Perez, Michele De Palma
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002746
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spelling doaj-f1879f53e6e2420f8c5c61d00a9e30d82021-04-08T04:19:05ZengElsevierCell Reports2211-12472021-04-01351108960Disentangling the complexity of tumor-derived extracellular vesiclesTim Beltraminelli0Caleb R. Perez1Michele De Palma2Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), 1015 Lausanne, Switzerland; Swiss Cancer Center Léman (SCCL), Lausanne, SwitzerlandSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), 1015 Lausanne, Switzerland; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USASwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), 1015 Lausanne, Switzerland; Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland; Corresponding authorSummary: The tumor microenvironment encompasses an intertwined ensemble of both transformed cancer cells and non-transformed host cells, which together establish a signaling network that regulates tumor progression. By conveying both homo- and heterotypic cell-to-cell communication cues, tumor-derived extracellular vesicles (tEVs) modulate several cancer-associated processes, such as immunosuppression, angiogenesis, invasion, and metastasis. Herein we discuss how recent methodological advances in the isolation and characterization of tEVs may help to broaden our understanding of their functions in tumor biology and, potentially, establish their utility as cancer biomarkers.http://www.sciencedirect.com/science/article/pii/S2211124721002746
collection DOAJ
language English
format Article
sources DOAJ
author Tim Beltraminelli
Caleb R. Perez
Michele De Palma
spellingShingle Tim Beltraminelli
Caleb R. Perez
Michele De Palma
Disentangling the complexity of tumor-derived extracellular vesicles
Cell Reports
author_facet Tim Beltraminelli
Caleb R. Perez
Michele De Palma
author_sort Tim Beltraminelli
title Disentangling the complexity of tumor-derived extracellular vesicles
title_short Disentangling the complexity of tumor-derived extracellular vesicles
title_full Disentangling the complexity of tumor-derived extracellular vesicles
title_fullStr Disentangling the complexity of tumor-derived extracellular vesicles
title_full_unstemmed Disentangling the complexity of tumor-derived extracellular vesicles
title_sort disentangling the complexity of tumor-derived extracellular vesicles
publisher Elsevier
series Cell Reports
issn 2211-1247
publishDate 2021-04-01
description Summary: The tumor microenvironment encompasses an intertwined ensemble of both transformed cancer cells and non-transformed host cells, which together establish a signaling network that regulates tumor progression. By conveying both homo- and heterotypic cell-to-cell communication cues, tumor-derived extracellular vesicles (tEVs) modulate several cancer-associated processes, such as immunosuppression, angiogenesis, invasion, and metastasis. Herein we discuss how recent methodological advances in the isolation and characterization of tEVs may help to broaden our understanding of their functions in tumor biology and, potentially, establish their utility as cancer biomarkers.
url http://www.sciencedirect.com/science/article/pii/S2211124721002746
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AT calebrperez disentanglingthecomplexityoftumorderivedextracellularvesicles
AT micheledepalma disentanglingthecomplexityoftumorderivedextracellularvesicles
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