Is kidney function associated with cognition and mood in late life?
Abstract Background Chronic kidney disease (CKD), cognitive impairment and depression share common risk factors. Previous studies did not investigate the possible association between kidney function and cognitive and mood disorders in older persons in a broad range of kidney function. The present st...
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2020-10-01
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Online Access: | http://link.springer.com/article/10.1186/s12877-020-01707-4 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lisanne Tap Andrea Corsonello Francesc Formiga Rafael Moreno-Gonzalez Johan Ärnlöv Axel C. Carlsson Regina Roller-Wirnsberger Gerhard Wirnsberger Gijsbertus Ziere Ellen Freiberger Cornel Sieber Tomasz Kostka Agnieszka Guligowska Pedro Gil Sara Lainez Martinez Rada Artzi-Medvedik Ilan Yehoshua Paolo Fabbietti Fabrizia Lattanzio Francesco Mattace-Raso on behalf of SCOPE investigators |
spellingShingle |
Lisanne Tap Andrea Corsonello Francesc Formiga Rafael Moreno-Gonzalez Johan Ärnlöv Axel C. Carlsson Regina Roller-Wirnsberger Gerhard Wirnsberger Gijsbertus Ziere Ellen Freiberger Cornel Sieber Tomasz Kostka Agnieszka Guligowska Pedro Gil Sara Lainez Martinez Rada Artzi-Medvedik Ilan Yehoshua Paolo Fabbietti Fabrizia Lattanzio Francesco Mattace-Raso on behalf of SCOPE investigators Is kidney function associated with cognition and mood in late life? BMC Geriatrics Chronic kidney disease Estimated glomerular filtration rate Cognition Cognitive impairment Mood Depressive symptoms |
author_facet |
Lisanne Tap Andrea Corsonello Francesc Formiga Rafael Moreno-Gonzalez Johan Ärnlöv Axel C. Carlsson Regina Roller-Wirnsberger Gerhard Wirnsberger Gijsbertus Ziere Ellen Freiberger Cornel Sieber Tomasz Kostka Agnieszka Guligowska Pedro Gil Sara Lainez Martinez Rada Artzi-Medvedik Ilan Yehoshua Paolo Fabbietti Fabrizia Lattanzio Francesco Mattace-Raso on behalf of SCOPE investigators |
author_sort |
Lisanne Tap |
title |
Is kidney function associated with cognition and mood in late life? |
title_short |
Is kidney function associated with cognition and mood in late life? |
title_full |
Is kidney function associated with cognition and mood in late life? |
title_fullStr |
Is kidney function associated with cognition and mood in late life? |
title_full_unstemmed |
Is kidney function associated with cognition and mood in late life? |
title_sort |
is kidney function associated with cognition and mood in late life? |
publisher |
BMC |
series |
BMC Geriatrics |
issn |
1471-2318 |
publishDate |
2020-10-01 |
description |
Abstract Background Chronic kidney disease (CKD), cognitive impairment and depression share common risk factors. Previous studies did not investigate the possible association between kidney function and cognitive and mood disorders in older persons in a broad range of kidney function. The present study explored associations between kidney function, cognition and mood in outpatients of 75 years and over. Methods Baseline data of 2252 participants of the SCOPE study, an international multicenter cohort observational study,were used in which community-dwelling persons of 75 years and over were enrolled to screen for CKD Kidney function was estimated with the BIS1-eGFR equation, cognition was assessed with the Mini-Mental State Examination (MMSE) and mood with the Geriatric Depression Scale 15 items (GDS-15). Characteristics were compared across stages of CKD. Mean eGFR values were also compared across categories of MMSE (< 24, 24–26, ≥27) and between groups with high and low score on the GDS-15 (> 5/≤5). Results In total, 63% of the population had an eGFR < 60 mL/min. In advanced stages of CKD, participants were older and more often men than in earlier stages (p < 0.001). Cardiovascular diseases and diabetes mellitus were more often found in those in advanced stages of CKD (p < 0.001), and also cumulative comorbidity scores were higher than in those in earlier stages (p < 0.001). Median MMSE was 29 in CKD stage 1–2 and 3, and 30 in CKD stage 4, whereas median GDS-15 score was 2 in all stages of CKD. Mean values of eGFR did not differ across categories of MMSE or between groups with high and low score on the GDS-15. Stratification for albuminuria did not change these results. Conclusions Older persons in more advanced stages of CKD did not have lower cognitive scores or higher rates of depressive symptoms than older persons in earlier stages. Future longitudinal studies might give information on the possible effect of kidney function on cognition and mood in late life. Trial registration This study was registered prospectively on 25th February 2016 at clinicaltrials.gov ( NCT02691546 ). |
topic |
Chronic kidney disease Estimated glomerular filtration rate Cognition Cognitive impairment Mood Depressive symptoms |
url |
http://link.springer.com/article/10.1186/s12877-020-01707-4 |
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doaj-f188fb44fe41496295f5e22b12c7031d2020-11-25T03:55:47ZengBMCBMC Geriatrics1471-23182020-10-0120S11910.1186/s12877-020-01707-4Is kidney function associated with cognition and mood in late life?Lisanne Tap0Andrea Corsonello1Francesc Formiga2Rafael Moreno-Gonzalez3Johan Ärnlöv4Axel C. Carlsson5Regina Roller-Wirnsberger6Gerhard Wirnsberger7Gijsbertus Ziere8Ellen Freiberger9Cornel Sieber10Tomasz Kostka11Agnieszka Guligowska12Pedro Gil13Sara Lainez Martinez14Rada Artzi-Medvedik15Ilan Yehoshua16Paolo Fabbietti17Fabrizia Lattanzio18Francesco Mattace-Raso19on behalf of SCOPE investigatorsDepartment of Internal Medicine, Section of Geriatric Medicine, Erasmus MC, University Medical Center RotterdamItalian National Research Center on Aging (IRCCS INRCA)Geriatric Unit, Internal Medicine Department, Bellvitge University Hospital-IDIBELL-L’Hospitalet de LlobregatGeriatric Unit, Internal Medicine Department, Bellvitge University Hospital-IDIBELL-L’Hospitalet de LlobregatDepartment of Medical Sciences, Uppsala UniversityDepartment of Medical Sciences, Uppsala UniversityDepartment of Internal Medicine, Medical University of GrazDepartment of Internal Medicine, Medical University of GrazDepartment of Internal Medicine, Section of Geriatric Medicine, Erasmus MC, University Medical Center RotterdamDepartment of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander Universität Erlangen-NürnbergDepartment of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander Universität Erlangen-NürnbergDepartment of Geriatrics, Healthy Ageing Research Centre, Medical University of LodzDepartment of Geriatrics, Healthy Ageing Research Centre, Medical University of LodzGeriatric Department, Hospital Clinico San CarlosGeriatric Department, Hospital Clinico San CarlosThe Recanati School for Community Health Professions at the faculty of Health Sciences, Ben-Gurion University of the NegevMaccabi Health OrganizationItalian National Research Center on Aging (IRCCS INRCA)Italian National Research Center on Aging (IRCCS INRCA)Department of Internal Medicine, Section of Geriatric Medicine, Erasmus MC, University Medical Center RotterdamAbstract Background Chronic kidney disease (CKD), cognitive impairment and depression share common risk factors. Previous studies did not investigate the possible association between kidney function and cognitive and mood disorders in older persons in a broad range of kidney function. The present study explored associations between kidney function, cognition and mood in outpatients of 75 years and over. Methods Baseline data of 2252 participants of the SCOPE study, an international multicenter cohort observational study,were used in which community-dwelling persons of 75 years and over were enrolled to screen for CKD Kidney function was estimated with the BIS1-eGFR equation, cognition was assessed with the Mini-Mental State Examination (MMSE) and mood with the Geriatric Depression Scale 15 items (GDS-15). Characteristics were compared across stages of CKD. Mean eGFR values were also compared across categories of MMSE (< 24, 24–26, ≥27) and between groups with high and low score on the GDS-15 (> 5/≤5). Results In total, 63% of the population had an eGFR < 60 mL/min. In advanced stages of CKD, participants were older and more often men than in earlier stages (p < 0.001). Cardiovascular diseases and diabetes mellitus were more often found in those in advanced stages of CKD (p < 0.001), and also cumulative comorbidity scores were higher than in those in earlier stages (p < 0.001). Median MMSE was 29 in CKD stage 1–2 and 3, and 30 in CKD stage 4, whereas median GDS-15 score was 2 in all stages of CKD. Mean values of eGFR did not differ across categories of MMSE or between groups with high and low score on the GDS-15. Stratification for albuminuria did not change these results. Conclusions Older persons in more advanced stages of CKD did not have lower cognitive scores or higher rates of depressive symptoms than older persons in earlier stages. Future longitudinal studies might give information on the possible effect of kidney function on cognition and mood in late life. Trial registration This study was registered prospectively on 25th February 2016 at clinicaltrials.gov ( NCT02691546 ).http://link.springer.com/article/10.1186/s12877-020-01707-4Chronic kidney diseaseEstimated glomerular filtration rateCognitionCognitive impairmentMoodDepressive symptoms |