Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?

Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?

We report a case of a female patient with Durie-Salmon stage 3A/ISS stage I IgG kappa multiple myeloma (MM) who developed encephalopathy after high-dose melphalan and hematopoietic stem cell transplant (HSCT). The most common etiologies for encephalopathy such as infection, narcotic medications, met...

Full description

Bibliographic Details
Main Authors: Diógenes Alayón-Laguer, Melissa Alsina, Jose L. Ochoa-Bayona, Ernesto Ayala
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Case Reports in Transplantation
Online Access:http://dx.doi.org/10.1155/2012/942795
id doaj-f189b0626517417f8fbd1c5b4b3a2533
record_format Article
spelling doaj-f189b0626517417f8fbd1c5b4b3a25332020-11-25T00:47:11ZengHindawi LimitedCase Reports in Transplantation2090-69432090-69512012-01-01201210.1155/2012/942795942795Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?Diógenes Alayón-Laguer0Melissa Alsina1Jose L. Ochoa-Bayona2Ernesto Ayala3Hematology-Oncology Program San Juan City Hospital and VA Caribbean Healthcare System, 10 Calle Casia, San Juan, PR 00921, USABlood an Marrow Transplantation Program, Moffitt Cancer Center, Tampa, FL 33612, USABlood an Marrow Transplantation Program, Moffitt Cancer Center, Tampa, FL 33612, USABlood an Marrow Transplantation Program, Moffitt Cancer Center, Tampa, FL 33612, USAWe report a case of a female patient with Durie-Salmon stage 3A/ISS stage I IgG kappa multiple myeloma (MM) who developed encephalopathy after high-dose melphalan and hematopoietic stem cell transplant (HSCT). The most common etiologies for encephalopathy such as infection, narcotic medications, metabolic-electrolyte disturbance, stroke, and central nervous system (CNS) hemorrhages were ruled out. The patient recovered from the altered mental status spontaneously. The possibilities of melphalan-induced encephalopathy versus critical-state delirium versus hypercytokinemia induce encephalopathy were contemplated.http://dx.doi.org/10.1155/2012/942795
collection DOAJ
language English
format Article
sources DOAJ
author Diógenes Alayón-Laguer
Melissa Alsina
Jose L. Ochoa-Bayona
Ernesto Ayala
spellingShingle Diógenes Alayón-Laguer
Melissa Alsina
Jose L. Ochoa-Bayona
Ernesto Ayala
Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?
Case Reports in Transplantation
author_facet Diógenes Alayón-Laguer
Melissa Alsina
Jose L. Ochoa-Bayona
Ernesto Ayala
author_sort Diógenes Alayón-Laguer
title Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?
title_short Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?
title_full Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?
title_fullStr Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?
title_full_unstemmed Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?
title_sort melphalan culprit or confounder in acute encephalopathy during autologous hematopoietic stem cell transplantation?
publisher Hindawi Limited
series Case Reports in Transplantation
issn 2090-6943
2090-6951
publishDate 2012-01-01
description We report a case of a female patient with Durie-Salmon stage 3A/ISS stage I IgG kappa multiple myeloma (MM) who developed encephalopathy after high-dose melphalan and hematopoietic stem cell transplant (HSCT). The most common etiologies for encephalopathy such as infection, narcotic medications, metabolic-electrolyte disturbance, stroke, and central nervous system (CNS) hemorrhages were ruled out. The patient recovered from the altered mental status spontaneously. The possibilities of melphalan-induced encephalopathy versus critical-state delirium versus hypercytokinemia induce encephalopathy were contemplated.
url http://dx.doi.org/10.1155/2012/942795
work_keys_str_mv AT diogenesalayonlaguer melphalanculpritorconfounderinacuteencephalopathyduringautologoushematopoieticstemcelltransplantation
AT melissaalsina melphalanculpritorconfounderinacuteencephalopathyduringautologoushematopoieticstemcelltransplantation
AT joselochoabayona melphalanculpritorconfounderinacuteencephalopathyduringautologoushematopoieticstemcelltransplantation
AT ernestoayala melphalanculpritorconfounderinacuteencephalopathyduringautologoushematopoieticstemcelltransplantation
_version_ 1725261365827862528

Similar Items