THE ANALYSIS OF THE RESULTS OF ACUTE LYMPHOBLAST LEUKEMIA TREATMENT IN CHILDREN USING A MODIFIED PROTOCOL COALL 92 IN ST. PETERSBURG

• Main Authors: E.G. Boichenko, M.B. Ivanovskaya, I.A. Garbuzova, M.A. Shul’gina, M.S. Livshits, T.N. Kulakova, T.A. Makarova, M.B. Belogurova, G.G. Radulesku, T.D. Viktorovich, E.D. Chavpetsova, M.M. Sokolova, Yu.S. Ogorodnikova, G.I. Uleiskaya
• Format: Article
• Language: English
• Published: Paediatrician Publishers, LLC 2006-06-01
• Series: Pediatričeskaâ Farmakologiâ
• Online Access: https://www.pedpharma.ru/jour/article/view/560
• ISSN: 1727-5776; 2500-3089

The article presents the results of the treatment of children with acute lymphoblast leukemia (all) according to the coall 92 program in St.-Petersburg from 01.01.1999 to 01.01.2005. 160 primary all patients, aged 4 months to 17 years 4 months were included in the study. International criteria were used to diagnose acute lymphoblast leukemia. A 2 years course of treatment in both risk groups included a 5,5–8 months phase of intensive chemotherapy followed by maintenance therapy. 6 years after the protocol introduction in the common group of patients the following survival rate indices were obtained: the 6 years uneventful survival rate was 63 ± 4,6%, the 6 years relapses free survival rate was 69 ± 4,7%, the 6 years general survival rate was 79 ± 3,7%.Key words: acute lymphoblast leukemia, children, intensive chemotherapy.