Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk
Objective: Epidemiologic studies investigating the association between dietary carbohydrates as well as glycemic index and glycemic load (markers of carbohydrate quality) and bladder cancer risk have yielded inconsistent results. The aim of the present meta-analysis is to summarize the evidence on t...
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2020-09-01
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doaj-f1984e19811d46c49646da2a3e7682972020-11-25T01:46:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-09-011010.3389/fonc.2020.530382530382Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer RiskHejia Zhu0Qiwang Mo1Qiwang Mo2Haixiang Shen3Song Wang4Ben Liu5Xin Xu6Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Urology, Shenzhou People's Hospital, Shenzhou, ChinaDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaObjective: Epidemiologic studies investigating the association between dietary carbohydrates as well as glycemic index and glycemic load (markers of carbohydrate quality) and bladder cancer risk have yielded inconsistent results. The aim of the present meta-analysis is to summarize the evidence on this association.Materials and Methods: A comprehensive literature search of articles published by December 2019 was performed in PubMed, Scopus, and Web of Science databases. A random-effects model was used to calculate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).Results: Twelve observational studies were included in the final analysis. There was no evidence of an association between consumption of carbohydrates and bladder cancer risk (pooled OR, 1.04; 95% CI, 0.92–1.17). No statistically significant association between glycemic load and bladder cancer was likewise found (pooled OR, 1.10; 95% CI, 0.85–1.42). However, there was a significant positive association between glycemic index and bladder cancer risk (pooled OR, 1.25; 95% CI, 1.11–1.41). In the dose–response analysis, the pooled OR (95% CI) per 10 units of glycemic index per day was 1.02 (95% CI, 1.01–1.04).Conclusion: In this meta-analysis, glycemic index showed a positive linear association with bladder cancer risk.https://www.frontiersin.org/article/10.3389/fonc.2020.530382/fullbladder cancercarbohydratesglycemic indexglycemic loadmeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hejia Zhu Qiwang Mo Qiwang Mo Haixiang Shen Song Wang Ben Liu Xin Xu |
spellingShingle |
Hejia Zhu Qiwang Mo Qiwang Mo Haixiang Shen Song Wang Ben Liu Xin Xu Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk Frontiers in Oncology bladder cancer carbohydrates glycemic index glycemic load meta-analysis |
author_facet |
Hejia Zhu Qiwang Mo Qiwang Mo Haixiang Shen Song Wang Ben Liu Xin Xu |
author_sort |
Hejia Zhu |
title |
Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_short |
Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_full |
Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_fullStr |
Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_full_unstemmed |
Carbohydrates, Glycemic Index, and Glycemic Load in Relation to Bladder Cancer Risk |
title_sort |
carbohydrates, glycemic index, and glycemic load in relation to bladder cancer risk |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-09-01 |
description |
Objective: Epidemiologic studies investigating the association between dietary carbohydrates as well as glycemic index and glycemic load (markers of carbohydrate quality) and bladder cancer risk have yielded inconsistent results. The aim of the present meta-analysis is to summarize the evidence on this association.Materials and Methods: A comprehensive literature search of articles published by December 2019 was performed in PubMed, Scopus, and Web of Science databases. A random-effects model was used to calculate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).Results: Twelve observational studies were included in the final analysis. There was no evidence of an association between consumption of carbohydrates and bladder cancer risk (pooled OR, 1.04; 95% CI, 0.92–1.17). No statistically significant association between glycemic load and bladder cancer was likewise found (pooled OR, 1.10; 95% CI, 0.85–1.42). However, there was a significant positive association between glycemic index and bladder cancer risk (pooled OR, 1.25; 95% CI, 1.11–1.41). In the dose–response analysis, the pooled OR (95% CI) per 10 units of glycemic index per day was 1.02 (95% CI, 1.01–1.04).Conclusion: In this meta-analysis, glycemic index showed a positive linear association with bladder cancer risk. |
topic |
bladder cancer carbohydrates glycemic index glycemic load meta-analysis |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.530382/full |
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