Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients
Abstract Background Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk factors of cerebrovascular disease. The purpose of the present study is to...
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doaj-f1a092434d584b3fb7aa289742dca1a82020-11-25T02:26:13ZengBMCBMC Nephrology1471-23692019-02-012011810.1186/s12882-019-1232-2Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patientsHonglan Wei0Hua Li1Xiaohong Song2Xingguo Du3Yuan Cai4Chengxu Li5Liping Dong6Junwu Dong7Department of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk factors of cerebrovascular disease. The purpose of the present study is to determine the relationship between serum klotho and cerebrovascular disease in patients receiving hemodialysis. Methods Serum klotho levels of hemodialysis patients were measured by ELISA. Cerebrovascular diseases were diagnosed by CT or MRI scans. The cognitive function of hemodialysis patients with cerebrovascular disease were evaluated with a neuropsychological battery assessing domains of global cognition verbal memory, spatial memory, executive function and verbal fluency. Results Eighty-eight patients were included, 57 ± 14 years, 63.64% male, 52.27% older than 60 years. Twenty-eight participants had cerebrovascular disease (23 cases had cerebral infarction, 5 cases had cerebral hemorrhage). The average level of serum klotho of all participants was 119.10 ± 47.29 pg/ml. The serum klotho level was significantly associated with cerebrovascular disease in hemodialysis patients (HR(95%CI) = 0.975(0.960–0.990), p = 0.001). The optimal cut-off value of serum klotho for predicting cerebrovascular disease in hemodialysis patients was 137.22 pg/ml, with a specificity of 96.4% and a sensitivity of 46.7%. But serum klotho was not an independent risk factor of cognitive impairment for hemodialysis patients with cerebrovascular disease (HR((95%CI) = 1.002(0.986–1.018), p = 0.776) or with cerebral infarction (HR(95%CI) = 1.005(0.987–1.023), p = 0.576). Conclusions The serum klotho level is a potential predictor of cerebrovascular disease in hemodialysis patients, but it is not an independent risk factor of cognitive impairment for hemodialysis patients with cerebrovascular disease.http://link.springer.com/article/10.1186/s12882-019-1232-2HemodialysisKlothoCerebrovascular diseaseCognitive impairment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Honglan Wei Hua Li Xiaohong Song Xingguo Du Yuan Cai Chengxu Li Liping Dong Junwu Dong |
spellingShingle |
Honglan Wei Hua Li Xiaohong Song Xingguo Du Yuan Cai Chengxu Li Liping Dong Junwu Dong Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients BMC Nephrology Hemodialysis Klotho Cerebrovascular disease Cognitive impairment |
author_facet |
Honglan Wei Hua Li Xiaohong Song Xingguo Du Yuan Cai Chengxu Li Liping Dong Junwu Dong |
author_sort |
Honglan Wei |
title |
Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients |
title_short |
Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients |
title_full |
Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients |
title_fullStr |
Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients |
title_full_unstemmed |
Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients |
title_sort |
serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2019-02-01 |
description |
Abstract Background Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk factors of cerebrovascular disease. The purpose of the present study is to determine the relationship between serum klotho and cerebrovascular disease in patients receiving hemodialysis. Methods Serum klotho levels of hemodialysis patients were measured by ELISA. Cerebrovascular diseases were diagnosed by CT or MRI scans. The cognitive function of hemodialysis patients with cerebrovascular disease were evaluated with a neuropsychological battery assessing domains of global cognition verbal memory, spatial memory, executive function and verbal fluency. Results Eighty-eight patients were included, 57 ± 14 years, 63.64% male, 52.27% older than 60 years. Twenty-eight participants had cerebrovascular disease (23 cases had cerebral infarction, 5 cases had cerebral hemorrhage). The average level of serum klotho of all participants was 119.10 ± 47.29 pg/ml. The serum klotho level was significantly associated with cerebrovascular disease in hemodialysis patients (HR(95%CI) = 0.975(0.960–0.990), p = 0.001). The optimal cut-off value of serum klotho for predicting cerebrovascular disease in hemodialysis patients was 137.22 pg/ml, with a specificity of 96.4% and a sensitivity of 46.7%. But serum klotho was not an independent risk factor of cognitive impairment for hemodialysis patients with cerebrovascular disease (HR((95%CI) = 1.002(0.986–1.018), p = 0.776) or with cerebral infarction (HR(95%CI) = 1.005(0.987–1.023), p = 0.576). Conclusions The serum klotho level is a potential predictor of cerebrovascular disease in hemodialysis patients, but it is not an independent risk factor of cognitive impairment for hemodialysis patients with cerebrovascular disease. |
topic |
Hemodialysis Klotho Cerebrovascular disease Cognitive impairment |
url |
http://link.springer.com/article/10.1186/s12882-019-1232-2 |
work_keys_str_mv |
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