Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery
Pentacyclic triterpenoids are well-known phytochemicals with various biological activities commonly found in plants as secondary metabolites. The wide range of biological activities exhibited by triterpenoids has made them the most valuable sources of pharmacological agents. A number of novel triter...
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doaj-f1a24562d4ba4fbcb027150b4bd9ce782021-04-21T23:00:13ZengMDPI AGMolecules1420-30492021-04-01262401240110.3390/molecules26092401Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug DiscoveryVuyolwethu Khwaza0Sithenkosi Mlala1Opeoluwa O. Oyedeji2Blessing A. Aderibigbe3Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South AfricaDepartment of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South AfricaDepartment of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South AfricaDepartment of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South AfricaPentacyclic triterpenoids are well-known phytochemicals with various biological activities commonly found in plants as secondary metabolites. The wide range of biological activities exhibited by triterpenoids has made them the most valuable sources of pharmacological agents. A number of novel triterpenoid derivatives with many skeletal modifications have been developed. The most important modifications are the formation of analogues or derivatives with nitrogen-containing heterocyclic scaffolds. The derivatives with nitrogen-containing heterocyclic compounds are among the most promising candidate for the development of novel therapeutic drugs. About 75% of FDA-approved drugs are nitrogen-containing heterocyclic moieties. The unique properties of heterocyclic compounds have encouraged many researchers to develop new triterpenoid analogous with pharmacological activities. In this review, we discuss recent advances of nitrogen-containing heterocyclic triterpenoids as potential therapeutic agents. This comprehensive review will assist medicinal chemists to understand new strategies that can result in the development of compounds with potential therapeutic efficacy.https://www.mdpi.com/1420-3049/26/9/2401pentacyclic triterpenoids<i>N</i>-heterocycleshybridsderivativesanticanceroleanolic acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vuyolwethu Khwaza Sithenkosi Mlala Opeoluwa O. Oyedeji Blessing A. Aderibigbe |
spellingShingle |
Vuyolwethu Khwaza Sithenkosi Mlala Opeoluwa O. Oyedeji Blessing A. Aderibigbe Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery Molecules pentacyclic triterpenoids <i>N</i>-heterocycles hybrids derivatives anticancer oleanolic acid |
author_facet |
Vuyolwethu Khwaza Sithenkosi Mlala Opeoluwa O. Oyedeji Blessing A. Aderibigbe |
author_sort |
Vuyolwethu Khwaza |
title |
Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery |
title_short |
Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery |
title_full |
Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery |
title_fullStr |
Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery |
title_full_unstemmed |
Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery |
title_sort |
pentacyclic triterpenoids with nitrogen-containing heterocyclic moiety, privileged hybrids in anticancer drug discovery |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-04-01 |
description |
Pentacyclic triterpenoids are well-known phytochemicals with various biological activities commonly found in plants as secondary metabolites. The wide range of biological activities exhibited by triterpenoids has made them the most valuable sources of pharmacological agents. A number of novel triterpenoid derivatives with many skeletal modifications have been developed. The most important modifications are the formation of analogues or derivatives with nitrogen-containing heterocyclic scaffolds. The derivatives with nitrogen-containing heterocyclic compounds are among the most promising candidate for the development of novel therapeutic drugs. About 75% of FDA-approved drugs are nitrogen-containing heterocyclic moieties. The unique properties of heterocyclic compounds have encouraged many researchers to develop new triterpenoid analogous with pharmacological activities. In this review, we discuss recent advances of nitrogen-containing heterocyclic triterpenoids as potential therapeutic agents. This comprehensive review will assist medicinal chemists to understand new strategies that can result in the development of compounds with potential therapeutic efficacy. |
topic |
pentacyclic triterpenoids <i>N</i>-heterocycles hybrids derivatives anticancer oleanolic acid |
url |
https://www.mdpi.com/1420-3049/26/9/2401 |
work_keys_str_mv |
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