Targeting ferroptosis in osteosarcoma
Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents, with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non-traditional mode of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid reactive oxygen species (ROS),...
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doaj-f1b66a9cb9634076bb8aefcd619c51cf2021-07-17T04:33:36ZengElsevierJournal of Bone Oncology2212-13742021-10-0130100380Targeting ferroptosis in osteosarcomaJiazheng Zhao0Yi Zhao1Xiaowei Ma2Benzheng Zhang3Helin Feng4Department of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, PR ChinaDepartment of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, PR ChinaDepartment of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, PR ChinaHebei Medical University, 361 Zhongshan East Road, Shijiazhuang, Hebei 050011, PR. ChinaDepartment of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei 050011, PR China; Corresponding author.Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents, with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non-traditional mode of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid reactive oxygen species (ROS), is closely associated with a variety of cancers. It has been demonstrated that ferroptosis can regulate OS progression and exert an essential role in the treatment of OS, which is potentially of great value. By targeting ferroptosis in OS, the present review article summarises the relevant mechanisms and therapeutic applications along with discussing current limitations and future directions, which may provide a new strategy for the treatment of OS.http://www.sciencedirect.com/science/article/pii/S221213742100035XFerroptosisOsteosarcomaTreatmentIronReactive oxygen species |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiazheng Zhao Yi Zhao Xiaowei Ma Benzheng Zhang Helin Feng |
spellingShingle |
Jiazheng Zhao Yi Zhao Xiaowei Ma Benzheng Zhang Helin Feng Targeting ferroptosis in osteosarcoma Journal of Bone Oncology Ferroptosis Osteosarcoma Treatment Iron Reactive oxygen species |
author_facet |
Jiazheng Zhao Yi Zhao Xiaowei Ma Benzheng Zhang Helin Feng |
author_sort |
Jiazheng Zhao |
title |
Targeting ferroptosis in osteosarcoma |
title_short |
Targeting ferroptosis in osteosarcoma |
title_full |
Targeting ferroptosis in osteosarcoma |
title_fullStr |
Targeting ferroptosis in osteosarcoma |
title_full_unstemmed |
Targeting ferroptosis in osteosarcoma |
title_sort |
targeting ferroptosis in osteosarcoma |
publisher |
Elsevier |
series |
Journal of Bone Oncology |
issn |
2212-1374 |
publishDate |
2021-10-01 |
description |
Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents, with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non-traditional mode of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid reactive oxygen species (ROS), is closely associated with a variety of cancers. It has been demonstrated that ferroptosis can regulate OS progression and exert an essential role in the treatment of OS, which is potentially of great value. By targeting ferroptosis in OS, the present review article summarises the relevant mechanisms and therapeutic applications along with discussing current limitations and future directions, which may provide a new strategy for the treatment of OS. |
topic |
Ferroptosis Osteosarcoma Treatment Iron Reactive oxygen species |
url |
http://www.sciencedirect.com/science/article/pii/S221213742100035X |
work_keys_str_mv |
AT jiazhengzhao targetingferroptosisinosteosarcoma AT yizhao targetingferroptosisinosteosarcoma AT xiaoweima targetingferroptosisinosteosarcoma AT benzhengzhang targetingferroptosisinosteosarcoma AT helinfeng targetingferroptosisinosteosarcoma |
_version_ |
1721297042458804224 |